Streptococcus pyogenes CovRS mediates growth in iron starvation and in the presence of the human cationic antimicrobial peptide LL-37

Barbara J. Froehlich, Christopher Bates, June R. Scott

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

We found that the global regulatory two-component signal transduction system CovRS mediates the ability of group A streptococcus (GAS) to grow under two stresses encountered during infection: iron starvation and the presence of LL-37. We also showed that CovRS regulates transcription of the multimetal transporter operon that is important for GAS growth in a low concentration of iron.

Original languageEnglish (US)
Pages (from-to)673-677
Number of pages5
JournalJournal of Bacteriology
Volume191
Issue number2
DOIs
StatePublished - Jan 2009

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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