Streptococcus pyogenes CovRS mediates growth in iron starvation and in the presence of the human cationic antimicrobial peptide LL-37

Barbara J. Froehlich, Christopher Bates, June R. Scott

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

We found that the global regulatory two-component signal transduction system CovRS mediates the ability of group A streptococcus (GAS) to grow under two stresses encountered during infection: iron starvation and the presence of LL-37. We also showed that CovRS regulates transcription of the multimetal transporter operon that is important for GAS growth in a low concentration of iron.

Original languageEnglish (US)
Pages (from-to)673-677
Number of pages5
JournalJournal of Bacteriology
Volume191
Issue number2
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

Fingerprint

Streptococcus pyogenes
Starvation
Streptococcus
Iron
Operon
Growth
Signal Transduction
Infection
antimicrobial peptide LL-37

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Cite this

Streptococcus pyogenes CovRS mediates growth in iron starvation and in the presence of the human cationic antimicrobial peptide LL-37. / Froehlich, Barbara J.; Bates, Christopher; Scott, June R.

In: Journal of Bacteriology, Vol. 191, No. 2, 01.01.2009, p. 673-677.

Research output: Contribution to journalArticle

@article{09cd5c73573447239991e8182646bbab,
title = "Streptococcus pyogenes CovRS mediates growth in iron starvation and in the presence of the human cationic antimicrobial peptide LL-37",
abstract = "We found that the global regulatory two-component signal transduction system CovRS mediates the ability of group A streptococcus (GAS) to grow under two stresses encountered during infection: iron starvation and the presence of LL-37. We also showed that CovRS regulates transcription of the multimetal transporter operon that is important for GAS growth in a low concentration of iron.",
author = "Froehlich, {Barbara J.} and Christopher Bates and Scott, {June R.}",
year = "2009",
month = "1",
day = "1",
doi = "10.1128/JB.01256-08",
language = "English (US)",
volume = "191",
pages = "673--677",
journal = "Journal of Bacteriology",
issn = "0021-9193",
publisher = "American Society for Microbiology",
number = "2",

}

TY - JOUR

T1 - Streptococcus pyogenes CovRS mediates growth in iron starvation and in the presence of the human cationic antimicrobial peptide LL-37

AU - Froehlich, Barbara J.

AU - Bates, Christopher

AU - Scott, June R.

PY - 2009/1/1

Y1 - 2009/1/1

N2 - We found that the global regulatory two-component signal transduction system CovRS mediates the ability of group A streptococcus (GAS) to grow under two stresses encountered during infection: iron starvation and the presence of LL-37. We also showed that CovRS regulates transcription of the multimetal transporter operon that is important for GAS growth in a low concentration of iron.

AB - We found that the global regulatory two-component signal transduction system CovRS mediates the ability of group A streptococcus (GAS) to grow under two stresses encountered during infection: iron starvation and the presence of LL-37. We also showed that CovRS regulates transcription of the multimetal transporter operon that is important for GAS growth in a low concentration of iron.

UR - http://www.scopus.com/inward/record.url?scp=58649083467&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58649083467&partnerID=8YFLogxK

U2 - 10.1128/JB.01256-08

DO - 10.1128/JB.01256-08

M3 - Article

C2 - 18996992

AN - SCOPUS:58649083467

VL - 191

SP - 673

EP - 677

JO - Journal of Bacteriology

JF - Journal of Bacteriology

SN - 0021-9193

IS - 2

ER -