Stress reduces diastolic function in youth

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: Research regarding the influence of mental stress (MS) on heart function focused primarily on heart contractility. We hypothesized that MS results in attenuated diastolic function (DF) as early as in adolescence and this effect may differ by race and sex. Methods: 161 normotensive adolescents (81 blacks and 80 females) performed resting (control) and MS (experimental) conditions on separate visits. Visits lasted for 3 hours (1-hour rest, video game challenge and recovery for experimental visit. Mitral inflow early (E) to late (A) filling velocities (E/A) ratio; mitral valve annular early velocity (E′) and E/E′ ratio were recorded every 30 minutes to evaluate DF. Results: BP and HR increased during experimental visit (all p values < .01). E/A ratio progressively increased during control visit (mean [SE], from 1.93 ± 0.42 to 2.01 ± 0.47) but decreased during the stress phase of experimental visit (from 1.91 ± 0.44 to 1.87 ± 0.50, p interaction < .001). In white males, E′ increased from rest to stress phase (from 10.3 ± 2.55 to 10.7 ± 2.28 cm/s), whereas E′ decreased in white females (from 11.0 ± 2.62 to 10.6 ± 2.53 cm/s), black males (from 10.5 ± 2.31 to 9.9 ± 2.19 cm/s), and black females (from 10.6 ± 2.22 to 10.3 ± 1.86 cm/s, p interaction < .04). During stress, higher A was associated with higher E/E′ ratio. Conclusions: Recurrent episodes of mental stress may increase the risk of poor DF, and these adverse effects may be stronger in females and black males.

Original languageEnglish (US)
Pages (from-to)588-595
Number of pages8
JournalPsychosomatic Medicine
Volume74
Issue number6
DOIs
StatePublished - Jan 1 2012

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Myocardial Contraction
Video Games
Mitral Valve
Research

Keywords

  • diastolic function
  • mental stress
  • youth

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

Cite this

Stress reduces diastolic function in youth. / Kapuku, Gaston K.; Davis, Harry; Murdison, Kenneth; Robinson, Vincent; Harshfield, Gregory.

In: Psychosomatic Medicine, Vol. 74, No. 6, 01.01.2012, p. 588-595.

Research output: Contribution to journalArticle

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abstract = "Objective: Research regarding the influence of mental stress (MS) on heart function focused primarily on heart contractility. We hypothesized that MS results in attenuated diastolic function (DF) as early as in adolescence and this effect may differ by race and sex. Methods: 161 normotensive adolescents (81 blacks and 80 females) performed resting (control) and MS (experimental) conditions on separate visits. Visits lasted for 3 hours (1-hour rest, video game challenge and recovery for experimental visit. Mitral inflow early (E) to late (A) filling velocities (E/A) ratio; mitral valve annular early velocity (E′) and E/E′ ratio were recorded every 30 minutes to evaluate DF. Results: BP and HR increased during experimental visit (all p values < .01). E/A ratio progressively increased during control visit (mean [SE], from 1.93 ± 0.42 to 2.01 ± 0.47) but decreased during the stress phase of experimental visit (from 1.91 ± 0.44 to 1.87 ± 0.50, p interaction < .001). In white males, E′ increased from rest to stress phase (from 10.3 ± 2.55 to 10.7 ± 2.28 cm/s), whereas E′ decreased in white females (from 11.0 ± 2.62 to 10.6 ± 2.53 cm/s), black males (from 10.5 ± 2.31 to 9.9 ± 2.19 cm/s), and black females (from 10.6 ± 2.22 to 10.3 ± 1.86 cm/s, p interaction < .04). During stress, higher A was associated with higher E/E′ ratio. Conclusions: Recurrent episodes of mental stress may increase the risk of poor DF, and these adverse effects may be stronger in females and black males.",
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