Abstract
Objective: Research regarding the influence of mental stress (MS) on heart function focused primarily on heart contractility. We hypothesized that MS results in attenuated diastolic function (DF) as early as in adolescence and this effect may differ by race and sex. Methods: 161 normotensive adolescents (81 blacks and 80 females) performed resting (control) and MS (experimental) conditions on separate visits. Visits lasted for 3 hours (1-hour rest, video game challenge and recovery for experimental visit. Mitral inflow early (E) to late (A) filling velocities (E/A) ratio; mitral valve annular early velocity (E′) and E/E′ ratio were recorded every 30 minutes to evaluate DF. Results: BP and HR increased during experimental visit (all p values < .01). E/A ratio progressively increased during control visit (mean [SE], from 1.93 ± 0.42 to 2.01 ± 0.47) but decreased during the stress phase of experimental visit (from 1.91 ± 0.44 to 1.87 ± 0.50, p interaction < .001). In white males, E′ increased from rest to stress phase (from 10.3 ± 2.55 to 10.7 ± 2.28 cm/s), whereas E′ decreased in white females (from 11.0 ± 2.62 to 10.6 ± 2.53 cm/s), black males (from 10.5 ± 2.31 to 9.9 ± 2.19 cm/s), and black females (from 10.6 ± 2.22 to 10.3 ± 1.86 cm/s, p interaction < .04). During stress, higher A was associated with higher E/E′ ratio. Conclusions: Recurrent episodes of mental stress may increase the risk of poor DF, and these adverse effects may be stronger in females and black males.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 588-595 |
| Number of pages | 8 |
| Journal | Psychosomatic Medicine |
| Volume | 74 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 2012 |
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Keywords
- diastolic function
- mental stress
- youth
ASJC Scopus subject areas
- Applied Psychology
- Psychiatry and Mental health
Cite this
Stress reduces diastolic function in youth. / Kapuku, Gaston K.; Davis, Harry; Murdison, Kenneth; Robinson, Vincent; Harshfield, Gregory.
In: Psychosomatic Medicine, Vol. 74, No. 6, 01.01.2012, p. 588-595.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stress reduces diastolic function in youth
AU - Kapuku, Gaston K.
AU - Davis, Harry
AU - Murdison, Kenneth
AU - Robinson, Vincent
AU - Harshfield, Gregory
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Objective: Research regarding the influence of mental stress (MS) on heart function focused primarily on heart contractility. We hypothesized that MS results in attenuated diastolic function (DF) as early as in adolescence and this effect may differ by race and sex. Methods: 161 normotensive adolescents (81 blacks and 80 females) performed resting (control) and MS (experimental) conditions on separate visits. Visits lasted for 3 hours (1-hour rest, video game challenge and recovery for experimental visit. Mitral inflow early (E) to late (A) filling velocities (E/A) ratio; mitral valve annular early velocity (E′) and E/E′ ratio were recorded every 30 minutes to evaluate DF. Results: BP and HR increased during experimental visit (all p values < .01). E/A ratio progressively increased during control visit (mean [SE], from 1.93 ± 0.42 to 2.01 ± 0.47) but decreased during the stress phase of experimental visit (from 1.91 ± 0.44 to 1.87 ± 0.50, p interaction < .001). In white males, E′ increased from rest to stress phase (from 10.3 ± 2.55 to 10.7 ± 2.28 cm/s), whereas E′ decreased in white females (from 11.0 ± 2.62 to 10.6 ± 2.53 cm/s), black males (from 10.5 ± 2.31 to 9.9 ± 2.19 cm/s), and black females (from 10.6 ± 2.22 to 10.3 ± 1.86 cm/s, p interaction < .04). During stress, higher A was associated with higher E/E′ ratio. Conclusions: Recurrent episodes of mental stress may increase the risk of poor DF, and these adverse effects may be stronger in females and black males.
AB - Objective: Research regarding the influence of mental stress (MS) on heart function focused primarily on heart contractility. We hypothesized that MS results in attenuated diastolic function (DF) as early as in adolescence and this effect may differ by race and sex. Methods: 161 normotensive adolescents (81 blacks and 80 females) performed resting (control) and MS (experimental) conditions on separate visits. Visits lasted for 3 hours (1-hour rest, video game challenge and recovery for experimental visit. Mitral inflow early (E) to late (A) filling velocities (E/A) ratio; mitral valve annular early velocity (E′) and E/E′ ratio were recorded every 30 minutes to evaluate DF. Results: BP and HR increased during experimental visit (all p values < .01). E/A ratio progressively increased during control visit (mean [SE], from 1.93 ± 0.42 to 2.01 ± 0.47) but decreased during the stress phase of experimental visit (from 1.91 ± 0.44 to 1.87 ± 0.50, p interaction < .001). In white males, E′ increased from rest to stress phase (from 10.3 ± 2.55 to 10.7 ± 2.28 cm/s), whereas E′ decreased in white females (from 11.0 ± 2.62 to 10.6 ± 2.53 cm/s), black males (from 10.5 ± 2.31 to 9.9 ± 2.19 cm/s), and black females (from 10.6 ± 2.22 to 10.3 ± 1.86 cm/s, p interaction < .04). During stress, higher A was associated with higher E/E′ ratio. Conclusions: Recurrent episodes of mental stress may increase the risk of poor DF, and these adverse effects may be stronger in females and black males.
KW - diastolic function
KW - mental stress
KW - youth
UR - http://www.scopus.com/inward/record.url?scp=84863728748&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863728748&partnerID=8YFLogxK
U2 - 10.1097/PSY.0b013e31825b920b
DO - 10.1097/PSY.0b013e31825b920b
M3 - Article
C2 - 22753631
AN - SCOPUS:84863728748
VL - 74
SP - 588
EP - 595
JO - Psychosomatic Medicine
JF - Psychosomatic Medicine
SN - 0033-3174
IS - 6
ER -