Stroke associated with ephedrine use

Askiel Bruno, Kurt B. Nolte, John Chapin

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Several sympathomimetic agents have been associated with ischemic and hemorrhagic stroke. Ephedrine, a sympathomimetic drug that has a high potential for abuse and can be readily obtained without a prescription in unrestricted quantities, has rarely been associated with stroke. We report ephedrine-related stroke in three patients. One patient developed a thalamic infarct after ingesting known quantities of ephedrine as street-purchased “speed” for weight loss. Two patients had fatal intracranial hemorrhages after ingesting unknown quantities of ephedrine; one of them had a history of drug abuse, and one lacked a history of ephedrine use or drug abuse. Ephedrine appears to predispose to both ischemic and hemorrhagic stroke. The mechanisms responsible for the different cerebrovascular complications remain to be proven. Restriction of ephedrine availability should be considered.

Original languageEnglish (US)
Pages (from-to)1313-1316
Number of pages4
JournalNeurology
Volume43
Issue number7
StatePublished - Jan 1 1993
Externally publishedYes

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Ephedrine
Stroke
Sympathomimetics
Substance-Related Disorders
Intracranial Hemorrhages
Prescriptions
Weight Loss

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Bruno, A., Nolte, K. B., & Chapin, J. (1993). Stroke associated with ephedrine use. Neurology, 43(7), 1313-1316.

Stroke associated with ephedrine use. / Bruno, Askiel; Nolte, Kurt B.; Chapin, John.

In: Neurology, Vol. 43, No. 7, 01.01.1993, p. 1313-1316.

Research output: Contribution to journalArticle

Bruno, A, Nolte, KB & Chapin, J 1993, 'Stroke associated with ephedrine use', Neurology, vol. 43, no. 7, pp. 1313-1316.
Bruno A, Nolte KB, Chapin J. Stroke associated with ephedrine use. Neurology. 1993 Jan 1;43(7):1313-1316.
Bruno, Askiel ; Nolte, Kurt B. ; Chapin, John. / Stroke associated with ephedrine use. In: Neurology. 1993 ; Vol. 43, No. 7. pp. 1313-1316.
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