TY - JOUR
T1 - Stromal cell-derived factor-1 (CXCL12) and its role in bone and muscle biology
AU - Gilbert, William
AU - Bragg, Robert
AU - Elmansi, Ahmed M.
AU - McGee Lawrence, Meghan Elizabeth
AU - Isales, Carlos M
AU - Hamrick, Mark W
AU - Hill, William D.
AU - Fulzele, Sadanand T
N1 - Funding Information:
This publication is based upon work supported in part by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research, and Development Program (VA Merit Award 1I01CX000930 01, W.D.H., S.F.,) and the National Institutes of Health (National Institute on Aging-AG036675 W.D.H., M.M.L., S.F., M.H., C.S.). The contents of this publication do not represent the views of the Department of Veterans Affairs or the U.S. Government. The above-mentioned funding did not lead to any conflict of interests regarding the publication of this manuscript.
Publisher Copyright:
© 2019
PY - 2019/11
Y1 - 2019/11
N2 - Musculoskeletal disorders are the leading cause of disability worldwide; two of the most prevalent of which are osteoporosis and sarcopenia. Each affect millions in the aging population across the world and the associated morbidity and mortality contributes to billions of dollars in annual healthcare cost. Thus, it is important to better understand the underlying pathologic mechanisms of the disease process. Regulatory chemokine, CXCL12, and its receptor, CXCR4, are recognized to be essential in the recruitment, localization, maintenance, development and differentiation of progenitor stem cells of the musculoskeletal system. CXCL12 signaling results in the development and functional ability of osteoblasts, osteoclasts, satellite cells and myoblasts critical to maintaining musculoskeletal homeostasis. Interestingly, one suggested pathologic mechanism of osteoporosis and sarcopenia is a decline in the regenerative capacity of musculoskeletal progenitor stem cells. Thus, because CXCL12 is critical to progenitor function, a disruption in the CXCL12 signaling axis might play a distinct role in these pathological processes. Therefore, in this article, we perform a review of CXCL12, its physiologic and pathologic function in bone and muscle, and potential targets for therapeutic development.
AB - Musculoskeletal disorders are the leading cause of disability worldwide; two of the most prevalent of which are osteoporosis and sarcopenia. Each affect millions in the aging population across the world and the associated morbidity and mortality contributes to billions of dollars in annual healthcare cost. Thus, it is important to better understand the underlying pathologic mechanisms of the disease process. Regulatory chemokine, CXCL12, and its receptor, CXCR4, are recognized to be essential in the recruitment, localization, maintenance, development and differentiation of progenitor stem cells of the musculoskeletal system. CXCL12 signaling results in the development and functional ability of osteoblasts, osteoclasts, satellite cells and myoblasts critical to maintaining musculoskeletal homeostasis. Interestingly, one suggested pathologic mechanism of osteoporosis and sarcopenia is a decline in the regenerative capacity of musculoskeletal progenitor stem cells. Thus, because CXCL12 is critical to progenitor function, a disruption in the CXCL12 signaling axis might play a distinct role in these pathological processes. Therefore, in this article, we perform a review of CXCL12, its physiologic and pathologic function in bone and muscle, and potential targets for therapeutic development.
KW - Bone
KW - Muscle
KW - Stromal cell-derived D factor-1 (CXCL12)
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U2 - 10.1016/j.cyto.2019.154783
DO - 10.1016/j.cyto.2019.154783
M3 - Review article
C2 - 31336263
AN - SCOPUS:85069606472
SN - 1043-4666
VL - 123
JO - Cytokine
JF - Cytokine
M1 - 154783
ER -