Structural Analysis of a Glycolipid Head Group with One- and Two-State NMR Pseudoenergy Approaches

J. N. Scarsdale, J. H. Prestegard, Robert K Yu

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

The solution conformation of the oligosaccharide head group of the glycolipid globoside has been determined with the use of 1 H two-dimensional NMR methods. The intensities of cross peaks in cross relaxation correlated experiments have been analyzed in terms of interproton distances, and the distances have been incorporated as a pseudoenergy in a conformational energy calculation. Minimum energy conformations have been determined by using both one- and two-state models. Conformations are consistent with a previously proposed “L” shape for the molecule. Comparison of the results from the two models suggests the possibility of conformational flexibility to exist for the terminal residue of the head group.

Original languageEnglish (US)
Pages (from-to)6778-6784
Number of pages7
JournalJournal of the American Chemical Society
Volume108
Issue number21
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Fingerprint Dive into the research topics of 'Structural Analysis of a Glycolipid Head Group with One- and Two-State NMR Pseudoenergy Approaches'. Together they form a unique fingerprint.

  • Cite this