Structural and functional brain asymmetries in human situs inversus totalis

David N. Kennedy, K. M. O'Craven, B. S. Ticho, A. M. Goldstein, N. Makris, John W. Henson

Research output: Contribution to journalArticlepeer-review

129 Scopus citations


Objective: To determine whether individuals with situs inversus totalis (SI), a condition in which there is a mirror-image reversal of asymmetric visceral organs, have alterations in brain asymmetries. Background: The human brain is asymmetric in structure and function. Although correlations between anatomic asymmetries and functional lateralization in human brain have been demonstrated, it has been difficult to further analyze them. Characterization of asymmetries of brain structure and function in SI might advance the understanding of these relationships. Methods: Using anatomic and functional MRI techniques, we analyzed asymmetries in the brains of three individuals with SI. Results: Two major anatomic asymmetries of the cerebral hemispheres, the frontal and occipital petalia, were reversed in individuals with SI. In contrast, SI subjects had left cerebral hemisphere language dominance on functional MRI analysis as well as strong right-handedness. Conclusion: These observations suggest that the developmental factors determining anatomic asymmetry of the cerebral petalia and viscera are distinct from those producing the functional lateralization of language.

Original languageEnglish (US)
Pages (from-to)1260-1265
Number of pages6
Issue number6
StatePublished - Oct 12 1999
Externally publishedYes


  • Asymmetry
  • Cerebral lateralization
  • Functional MRI
  • Language lateralization
  • Situs inversus totalis

ASJC Scopus subject areas

  • Clinical Neurology


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