Structural considerations of autoantibodies

Michael P. Madaio, Y. Naparstek

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The mechanisms responsible for peptide-induced immunosuppression lupus-prone BWF1 mice were determined to be mediated via recognition by T cells, although the response was peptide-specific, as some accelerated the autoimmune response. Furthermore, this was associated with suppression of IFN-g and IL-4 in serum and increased TGF-b. Recent isolation of peptide-specific T cells should be helpful in sorting out the mechanisms responsible for these events. In separate studies, it was demonstrated that an anti-DNA antibody that enters cells is able to transport proteins linked to it, supporting the possibility that this system can be used as a therapeutic modality to modify specific cellular activities.

Original languageEnglish (US)
Pages (from-to)774-775
Number of pages2
JournalLupus
Volume11
Issue number12
DOIs
StatePublished - Dec 1 2002
Externally publishedYes

Keywords

  • Autoantibodies
  • Cytokines
  • Drug delivery
  • Immunlogic tolerance
  • T cells

ASJC Scopus subject areas

  • Rheumatology
  • Medicine(all)

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  • Cite this

    Madaio, M. P., & Naparstek, Y. (2002). Structural considerations of autoantibodies. Lupus, 11(12), 774-775. https://doi.org/10.1191/0961203302lu314rp