Abstract
The mechanisms responsible for peptide-induced immunosuppression lupus-prone BWF1 mice were determined to be mediated via recognition by T cells, although the response was peptide-specific, as some accelerated the autoimmune response. Furthermore, this was associated with suppression of IFN-g and IL-4 in serum and increased TGF-b. Recent isolation of peptide-specific T cells should be helpful in sorting out the mechanisms responsible for these events. In separate studies, it was demonstrated that an anti-DNA antibody that enters cells is able to transport proteins linked to it, supporting the possibility that this system can be used as a therapeutic modality to modify specific cellular activities.
Original language | English (US) |
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Pages (from-to) | 774-775 |
Number of pages | 2 |
Journal | Lupus |
Volume | 11 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1 2002 |
Externally published | Yes |
Keywords
- Autoantibodies
- Cytokines
- Drug delivery
- Immunlogic tolerance
- T cells
ASJC Scopus subject areas
- Rheumatology
- General Medicine