Structural properties of a subset of nephritogenic anti-DNA antibodies

Thomas Kieber-Emmons, Mary H. Foster, William V. Williams, Michael P. Madaio

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Structural analysis of lupus autoantibodies is beginning to provide clues to the molecular basis for antigenic specificity and pathogenicity. The present analysis indicates that multiple light and heavy chains contain residues which can facilitate DNA binding, reaffirming the notion that there are multiple ways that different amino acids combine to form an antigen-binding pocket with affinity for dsDNA and ssDNA. Furthermore, this analysis suggests that these conformations and contact residues are intrinsic to germline sequences, although amino acid changes at critical locations (somatically introduced) modulate antigen binding, and appear to influence the capacity of individual immunoglobulin to form immune deposits. Analysis of additional individual immunoglobulins with closely related V-region sequences and differing pathogenic properties will be required to resolve the contribution of specific motifs to pathogenecity.

Original languageEnglish (US)
Pages (from-to)172-185
Number of pages14
JournalImmunologic Research
Volume13
Issue number2-3
DOIs
StatePublished - Jun 1 1994

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Antinuclear Antibodies
Immunoglobulins
Antigens
Autoantibodies
Virulence
Epitopes
Amino Acid Sequence
Light
Amino Acids
DNA

Keywords

  • Anti-DNA
  • Antibody modeling
  • Autoantibody
  • V gene, variable-region genes

ASJC Scopus subject areas

  • Immunology

Cite this

Kieber-Emmons, T., Foster, M. H., Williams, W. V., & Madaio, M. P. (1994). Structural properties of a subset of nephritogenic anti-DNA antibodies. Immunologic Research, 13(2-3), 172-185. https://doi.org/10.1007/BF02918278

Structural properties of a subset of nephritogenic anti-DNA antibodies. / Kieber-Emmons, Thomas; Foster, Mary H.; Williams, William V.; Madaio, Michael P.

In: Immunologic Research, Vol. 13, No. 2-3, 01.06.1994, p. 172-185.

Research output: Contribution to journalArticle

Kieber-Emmons, T, Foster, MH, Williams, WV & Madaio, MP 1994, 'Structural properties of a subset of nephritogenic anti-DNA antibodies', Immunologic Research, vol. 13, no. 2-3, pp. 172-185. https://doi.org/10.1007/BF02918278
Kieber-Emmons T, Foster MH, Williams WV, Madaio MP. Structural properties of a subset of nephritogenic anti-DNA antibodies. Immunologic Research. 1994 Jun 1;13(2-3):172-185. https://doi.org/10.1007/BF02918278
Kieber-Emmons, Thomas ; Foster, Mary H. ; Williams, William V. ; Madaio, Michael P. / Structural properties of a subset of nephritogenic anti-DNA antibodies. In: Immunologic Research. 1994 ; Vol. 13, No. 2-3. pp. 172-185.
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