Structural versus functional prediction of memory change following anterior temporal lobectomy

David W. Loring, Kimford J. Meador, Gregory P Lee, Joseph R. Smith

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Decline in recent memory function is a significant risk for patients undergoing anterior temporal lobectomy. We report a patient with a febrile seizure history, complex partial seizures arising from the left anterior temporal lobe, and MRI evidence suggesting left hippocampal sclerosis, all of which indicate a low likelihood of significant postoperative memory decline. However, high normal verbal memory on neuropsychological testing and bilaterally normal Wada memory scores indicated increased risk for postoperative memory decline. Following left anterior temporal lobectomy, the patient displayed a significant decline in verbal recent memory that affected school performance. Despite the worsening in memory, the patient reported a significant improvement in his self-reported quality-of-life perception, demonstrating that factors other than change in cognitive performance are related to whether a patient considers epilepsy surgery worthwhile. In the present case, behavioral measures were superior to structural measures in predicting cognitive change following surgery.

Original languageEnglish (US)
Pages (from-to)264-268
Number of pages5
JournalEpilepsy and Behavior
Volume5
Issue number2
DOIs
StatePublished - Jan 1 2004

    Fingerprint

Keywords

  • Hippocampus
  • Intracarotid amobarbital procedure
  • Magnetic resonance imaging
  • Memory
  • Neuropsychological testing
  • Temporal lobectomy
  • Wada test

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

Cite this