Structure-Activity Relationship Studies of Cocaine: Replacement of the C-2 Ester Group by Vinyl Argues against H-Bonding and Provides an Esterase-Resistant, High-Affinity Cocaine Analogue

Alan P. Kozikowski, Marinella Roberti, Xiang Li Xiang, John S. Bergmann, Patrick Michael Callahan, Kathryn A. Cunningham, Kenneth M. Johnson

Research output: Contribution to journalArticle

71 Citations (Scopus)
Original languageEnglish (US)
Pages (from-to)4764-4766
Number of pages3
JournalJournal of Medicinal Chemistry
Volume35
Issue number25
DOIs
StatePublished - Dec 1 1992
Externally publishedYes

Fingerprint

Mazindol
Discrimination Learning
Competitive Binding
Esterases
Structure-Activity Relationship
Cocaine
Brain
calcium ascorbate

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Structure-Activity Relationship Studies of Cocaine : Replacement of the C-2 Ester Group by Vinyl Argues against H-Bonding and Provides an Esterase-Resistant, High-Affinity Cocaine Analogue. / Kozikowski, Alan P.; Roberti, Marinella; Li Xiang, Xiang; Bergmann, John S.; Callahan, Patrick Michael; Cunningham, Kathryn A.; Johnson, Kenneth M.

In: Journal of Medicinal Chemistry, Vol. 35, No. 25, 01.12.1992, p. 4764-4766.

Research output: Contribution to journalArticle

Kozikowski, Alan P. ; Roberti, Marinella ; Li Xiang, Xiang ; Bergmann, John S. ; Callahan, Patrick Michael ; Cunningham, Kathryn A. ; Johnson, Kenneth M. / Structure-Activity Relationship Studies of Cocaine : Replacement of the C-2 Ester Group by Vinyl Argues against H-Bonding and Provides an Esterase-Resistant, High-Affinity Cocaine Analogue. In: Journal of Medicinal Chemistry. 1992 ; Vol. 35, No. 25. pp. 4764-4766.
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