Structure-Activity Relationship Studies of Cocaine: Replacement of the C-2 Ester Group by Vinyl Argues against H-Bonding and Provides an Esterase-Resistant, High-Affinity Cocaine Analogue

Alan P. Kozikowski; Marinella Roberti; Xiang Li Xiang; John S. Bergmann; Patrick Michael Callahan; Kathryn A. Cunningham; Kenneth M. Johnson

doi:10.1021/jm00103a015

Structure-Activity Relationship Studies of Cocaine: Replacement of the C-2 Ester Group by Vinyl Argues against H-Bonding and Provides an Esterase-Resistant, High-Affinity Cocaine Analogue

Alan P. Kozikowski, Marinella Roberti, Xiang Li Xiang, John S. Bergmann, Patrick Michael Callahan, Kathryn A. Cunningham, Kenneth M. Johnson

Research output: Contribution to journal › Article

71 Scopus citations

Original language	English (US)
Pages (from-to)	4764-4766
Number of pages	3
Journal	Journal of Medicinal Chemistry
Volume	35
Issue number	25
DOIs	https://doi.org/10.1021/jm00103a015
State	Published - Dec 1 1992
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

Access to Document

10.1021/jm00103a015

Cite this

Kozikowski, A. P., Roberti, M., Li Xiang, X., Bergmann, J. S., Callahan, P. M., Cunningham, K. A., & Johnson, K. M. (1992). Structure-Activity Relationship Studies of Cocaine: Replacement of the C-2 Ester Group by Vinyl Argues against H-Bonding and Provides an Esterase-Resistant, High-Affinity Cocaine Analogue. Journal of Medicinal Chemistry, 35(25), 4764-4766. https://doi.org/10.1021/jm00103a015

Structure-Activity Relationship Studies of Cocaine : Replacement of the C-2 Ester Group by Vinyl Argues against H-Bonding and Provides an Esterase-Resistant, High-Affinity Cocaine Analogue. / Kozikowski, Alan P.; Roberti, Marinella; Li Xiang, Xiang; Bergmann, John S.; Callahan, Patrick Michael; Cunningham, Kathryn A.; Johnson, Kenneth M.

In: Journal of Medicinal Chemistry, Vol. 35, No. 25, 01.12.1992, p. 4764-4766.

Research output: Contribution to journal › Article

Kozikowski, AP, Roberti, M, Li Xiang, X, Bergmann, JS, Callahan, PM, Cunningham, KA & Johnson, KM 1992, 'Structure-Activity Relationship Studies of Cocaine: Replacement of the C-2 Ester Group by Vinyl Argues against H-Bonding and Provides an Esterase-Resistant, High-Affinity Cocaine Analogue', Journal of Medicinal Chemistry, vol. 35, no. 25, pp. 4764-4766. https://doi.org/10.1021/jm00103a015

Kozikowski AP, Roberti M, Li Xiang X, Bergmann JS, Callahan PM, Cunningham KA et al. Structure-Activity Relationship Studies of Cocaine: Replacement of the C-2 Ester Group by Vinyl Argues against H-Bonding and Provides an Esterase-Resistant, High-Affinity Cocaine Analogue. Journal of Medicinal Chemistry. 1992 Dec 1;35(25):4764-4766. https://doi.org/10.1021/jm00103a015

Kozikowski, Alan P. ; Roberti, Marinella ; Li Xiang, Xiang ; Bergmann, John S. ; Callahan, Patrick Michael ; Cunningham, Kathryn A. ; Johnson, Kenneth M. / Structure-Activity Relationship Studies of Cocaine : Replacement of the C-2 Ester Group by Vinyl Argues against H-Bonding and Provides an Esterase-Resistant, High-Affinity Cocaine Analogue. In: Journal of Medicinal Chemistry. 1992 ; Vol. 35, No. 25. pp. 4764-4766.

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