Structured cueing on a semantic fluency task differentiates patients with temporal versus frontal lobe seizure onset

Daniel L. Drane, Gregory P Lee, Helen Cech, Justin S. Huthwaite, George A. Ojemann, Jeffrey G. Ojemann, David W. Loring, Kimford J. Meador

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Patients with frontal lobe dysfunction (e.g., Huntington's disease) reportedly benefit more from cueing on measures of semantic fluency than do patients with damage to temporal lobe structures (e.g., Alzheimer's disease). This differential benefit from cueing suggests that different neurocognitive functions are impaired in these two groups. Patients with frontal lobe dysfunction are presumed to have difficulty with the executive aspects of this generative fluency task, whereas patients with temporal lobe impairment are limited by deficits in semantic memory. We studied the performance of patients with complex partial seizures of frontal or temporal lobe onset, as determined by video/EEG monitoring, on standard and cued measures of semantic fluency administered in a counterbalanced sequence across groups. These groups did not differ significantly in terms of age, education, gender, age at seizure onset, total number of antiepileptic drugs, or IQ, and all patients subsequently underwent surgery for intractable epilepsy. Patients with frontal lobe dysfunction (FL group) performed significantly worse than patients with temporal lobe impairment (TL group) on the standard semantic fluency paradigm (TL group: M = 18.4, SD = 4.7; FL group: M = 11.1, SD = 5.3), t (27) = -3.75, P < 0.001. Nevertheless, results of an ANCOVA demonstrated that the FL group showed significantly greater performance improvement than the TL group when provided with a cued semantic fluency format, even after controlling for baseline differences in ability on the standard semantic fluency task (TL group: M = 0.45, SD = 3.8; FL M = 9.4, SD = 5.1), F (1, 29) = 12.37, P = 0.002. These findings support previous research suggesting that frontal and temporal structures contribute uniquely to semantic generative fluency and suggest that using a combination of standard and cued semantic fluency tasks may help confirm localization of seizure onset in partial epilepsy by localizing the associated cognitive dysfunction.

Original languageEnglish (US)
Pages (from-to)339-344
Number of pages6
JournalEpilepsy and Behavior
Volume9
Issue number2
DOIs
StatePublished - Sep 1 2006

Fingerprint

Frontal Lobe
Semantics
Seizures
Temporal Lobe
Aptitude
Partial Epilepsy
Huntington Disease
Age of Onset
Anticonvulsants
Electroencephalography
Alzheimer Disease
Education
Research

Keywords

  • Frontal and temporal lobe epilepsy
  • Localization of seizures
  • Semantic fluency

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

Cite this

Drane, D. L., Lee, G. P., Cech, H., Huthwaite, J. S., Ojemann, G. A., Ojemann, J. G., ... Meador, K. J. (2006). Structured cueing on a semantic fluency task differentiates patients with temporal versus frontal lobe seizure onset. Epilepsy and Behavior, 9(2), 339-344. https://doi.org/10.1016/j.yebeh.2006.06.010

Structured cueing on a semantic fluency task differentiates patients with temporal versus frontal lobe seizure onset. / Drane, Daniel L.; Lee, Gregory P; Cech, Helen; Huthwaite, Justin S.; Ojemann, George A.; Ojemann, Jeffrey G.; Loring, David W.; Meador, Kimford J.

In: Epilepsy and Behavior, Vol. 9, No. 2, 01.09.2006, p. 339-344.

Research output: Contribution to journalArticle

Drane, DL, Lee, GP, Cech, H, Huthwaite, JS, Ojemann, GA, Ojemann, JG, Loring, DW & Meador, KJ 2006, 'Structured cueing on a semantic fluency task differentiates patients with temporal versus frontal lobe seizure onset', Epilepsy and Behavior, vol. 9, no. 2, pp. 339-344. https://doi.org/10.1016/j.yebeh.2006.06.010
Drane, Daniel L. ; Lee, Gregory P ; Cech, Helen ; Huthwaite, Justin S. ; Ojemann, George A. ; Ojemann, Jeffrey G. ; Loring, David W. ; Meador, Kimford J. / Structured cueing on a semantic fluency task differentiates patients with temporal versus frontal lobe seizure onset. In: Epilepsy and Behavior. 2006 ; Vol. 9, No. 2. pp. 339-344.
@article{e85ce3278ef34c99bbc990ff9334fa1c,
title = "Structured cueing on a semantic fluency task differentiates patients with temporal versus frontal lobe seizure onset",
abstract = "Patients with frontal lobe dysfunction (e.g., Huntington's disease) reportedly benefit more from cueing on measures of semantic fluency than do patients with damage to temporal lobe structures (e.g., Alzheimer's disease). This differential benefit from cueing suggests that different neurocognitive functions are impaired in these two groups. Patients with frontal lobe dysfunction are presumed to have difficulty with the executive aspects of this generative fluency task, whereas patients with temporal lobe impairment are limited by deficits in semantic memory. We studied the performance of patients with complex partial seizures of frontal or temporal lobe onset, as determined by video/EEG monitoring, on standard and cued measures of semantic fluency administered in a counterbalanced sequence across groups. These groups did not differ significantly in terms of age, education, gender, age at seizure onset, total number of antiepileptic drugs, or IQ, and all patients subsequently underwent surgery for intractable epilepsy. Patients with frontal lobe dysfunction (FL group) performed significantly worse than patients with temporal lobe impairment (TL group) on the standard semantic fluency paradigm (TL group: M = 18.4, SD = 4.7; FL group: M = 11.1, SD = 5.3), t (27) = -3.75, P < 0.001. Nevertheless, results of an ANCOVA demonstrated that the FL group showed significantly greater performance improvement than the TL group when provided with a cued semantic fluency format, even after controlling for baseline differences in ability on the standard semantic fluency task (TL group: M = 0.45, SD = 3.8; FL M = 9.4, SD = 5.1), F (1, 29) = 12.37, P = 0.002. These findings support previous research suggesting that frontal and temporal structures contribute uniquely to semantic generative fluency and suggest that using a combination of standard and cued semantic fluency tasks may help confirm localization of seizure onset in partial epilepsy by localizing the associated cognitive dysfunction.",
keywords = "Frontal and temporal lobe epilepsy, Localization of seizures, Semantic fluency",
author = "Drane, {Daniel L.} and Lee, {Gregory P} and Helen Cech and Huthwaite, {Justin S.} and Ojemann, {George A.} and Ojemann, {Jeffrey G.} and Loring, {David W.} and Meador, {Kimford J.}",
year = "2006",
month = "9",
day = "1",
doi = "10.1016/j.yebeh.2006.06.010",
language = "English (US)",
volume = "9",
pages = "339--344",
journal = "Epilepsy and Behavior",
issn = "1525-5050",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Structured cueing on a semantic fluency task differentiates patients with temporal versus frontal lobe seizure onset

AU - Drane, Daniel L.

AU - Lee, Gregory P

AU - Cech, Helen

AU - Huthwaite, Justin S.

AU - Ojemann, George A.

AU - Ojemann, Jeffrey G.

AU - Loring, David W.

AU - Meador, Kimford J.

PY - 2006/9/1

Y1 - 2006/9/1

N2 - Patients with frontal lobe dysfunction (e.g., Huntington's disease) reportedly benefit more from cueing on measures of semantic fluency than do patients with damage to temporal lobe structures (e.g., Alzheimer's disease). This differential benefit from cueing suggests that different neurocognitive functions are impaired in these two groups. Patients with frontal lobe dysfunction are presumed to have difficulty with the executive aspects of this generative fluency task, whereas patients with temporal lobe impairment are limited by deficits in semantic memory. We studied the performance of patients with complex partial seizures of frontal or temporal lobe onset, as determined by video/EEG monitoring, on standard and cued measures of semantic fluency administered in a counterbalanced sequence across groups. These groups did not differ significantly in terms of age, education, gender, age at seizure onset, total number of antiepileptic drugs, or IQ, and all patients subsequently underwent surgery for intractable epilepsy. Patients with frontal lobe dysfunction (FL group) performed significantly worse than patients with temporal lobe impairment (TL group) on the standard semantic fluency paradigm (TL group: M = 18.4, SD = 4.7; FL group: M = 11.1, SD = 5.3), t (27) = -3.75, P < 0.001. Nevertheless, results of an ANCOVA demonstrated that the FL group showed significantly greater performance improvement than the TL group when provided with a cued semantic fluency format, even after controlling for baseline differences in ability on the standard semantic fluency task (TL group: M = 0.45, SD = 3.8; FL M = 9.4, SD = 5.1), F (1, 29) = 12.37, P = 0.002. These findings support previous research suggesting that frontal and temporal structures contribute uniquely to semantic generative fluency and suggest that using a combination of standard and cued semantic fluency tasks may help confirm localization of seizure onset in partial epilepsy by localizing the associated cognitive dysfunction.

AB - Patients with frontal lobe dysfunction (e.g., Huntington's disease) reportedly benefit more from cueing on measures of semantic fluency than do patients with damage to temporal lobe structures (e.g., Alzheimer's disease). This differential benefit from cueing suggests that different neurocognitive functions are impaired in these two groups. Patients with frontal lobe dysfunction are presumed to have difficulty with the executive aspects of this generative fluency task, whereas patients with temporal lobe impairment are limited by deficits in semantic memory. We studied the performance of patients with complex partial seizures of frontal or temporal lobe onset, as determined by video/EEG monitoring, on standard and cued measures of semantic fluency administered in a counterbalanced sequence across groups. These groups did not differ significantly in terms of age, education, gender, age at seizure onset, total number of antiepileptic drugs, or IQ, and all patients subsequently underwent surgery for intractable epilepsy. Patients with frontal lobe dysfunction (FL group) performed significantly worse than patients with temporal lobe impairment (TL group) on the standard semantic fluency paradigm (TL group: M = 18.4, SD = 4.7; FL group: M = 11.1, SD = 5.3), t (27) = -3.75, P < 0.001. Nevertheless, results of an ANCOVA demonstrated that the FL group showed significantly greater performance improvement than the TL group when provided with a cued semantic fluency format, even after controlling for baseline differences in ability on the standard semantic fluency task (TL group: M = 0.45, SD = 3.8; FL M = 9.4, SD = 5.1), F (1, 29) = 12.37, P = 0.002. These findings support previous research suggesting that frontal and temporal structures contribute uniquely to semantic generative fluency and suggest that using a combination of standard and cued semantic fluency tasks may help confirm localization of seizure onset in partial epilepsy by localizing the associated cognitive dysfunction.

KW - Frontal and temporal lobe epilepsy

KW - Localization of seizures

KW - Semantic fluency

UR - http://www.scopus.com/inward/record.url?scp=33747852305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33747852305&partnerID=8YFLogxK

U2 - 10.1016/j.yebeh.2006.06.010

DO - 10.1016/j.yebeh.2006.06.010

M3 - Article

VL - 9

SP - 339

EP - 344

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

SN - 1525-5050

IS - 2

ER -