Studies on the mechanism of bowel disturbance in ulcerative colitis

S. S.C. Rao, N. W. Read, C. Brown, C. Bruce, C. D. Holdsworth

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

The transit of a radiolabeled meal through the gastrointestinal tract and stool output were measured in 62 patients with ulcerative colitis, subdivided according to the activity and extent of their disease. The results were compared with those from 20 sex-matched normal subjects. Mouth-to-cecum transit was significantly slower than normal in all patient groups although gastric emptying was normal. Whole gut transit was not accelerated in any group of patients. An abdominal x-ray taken 48 h after ingesting the meal showed that patients with active colitis had proximal colonic stasis, whereas transit through the rectosigmoid region was rapid. Stool weights and frequencies were higher in patients with active colitis than in patients with quiescent disease. Patients with active colitis also passed smaller amounts of stool during each bowel movement, suggesting that they experienced a desire to defecate at lower rectal volumes. These results indicate that (a) diarrhea in ulcerative colitis is associated with rectosigmoid irritability rather than rapid transit and (b) caution should be used when treating active colitis with antidiarrheal drugs that could further retard proximal colonic transit.

Original languageEnglish (US)
Pages (from-to)934-940
Number of pages7
JournalGastroenterology
Volume93
Issue number5
DOIs
StatePublished - Nov 1987
Externally publishedYes

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Ulcerative Colitis
Colitis
Meals
Antidiarrheals
Cecum
Gastric Emptying
Mouth
Gastrointestinal Tract
Diarrhea
X-Rays
Weights and Measures

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Studies on the mechanism of bowel disturbance in ulcerative colitis. / Rao, S. S.C.; Read, N. W.; Brown, C.; Bruce, C.; Holdsworth, C. D.

In: Gastroenterology, Vol. 93, No. 5, 11.1987, p. 934-940.

Research output: Contribution to journalArticle

Rao, S. S.C. ; Read, N. W. ; Brown, C. ; Bruce, C. ; Holdsworth, C. D. / Studies on the mechanism of bowel disturbance in ulcerative colitis. In: Gastroenterology. 1987 ; Vol. 93, No. 5. pp. 934-940.
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