Abstract
Unprotected S-acylated cysteine isopeptides containing α-, β- or γ-amino acid units have been synthesized, and their conversion to native hexapeptides by S- to the N-terminus ligations involving 17-, 18- and 19-membered cyclic transition states have been demonstrated both experimentally and computationally to be more favorable than intermolecular cross-ligations.
Original language | English (US) |
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Pages (from-to) | 821-7 |
Number of pages | 7 |
Journal | Chemical Biology and Drug Design |
Volume | 80 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2012 |
Keywords
- Cysteine
- Molecular Conformation
- Nitrogen
- Peptides
- Sulfur
- Journal Article
- Research Support, Non-U.S. Gov't