Unprotected S-acylated cysteine isopeptides containing α-, β- or γ-amino acid units have been synthesized, and their conversion to native hexapeptides by S- to the N-terminus ligations involving 17-, 18- and 19-membered cyclic transition states have been demonstrated both experimentally and computationally to be more favorable than intermolecular cross-ligations.
|Original language||English (US)|
|Number of pages||7|
|Journal||Chemical Biology and Drug Design|
|State||Published - Dec 2012|
- Molecular Conformation
- Journal Article
- Research Support, Non-U.S. Gov't