Study of chemical ligation via 17-, 18- and 19-membered cyclic transition states

Research output: Contribution to journalArticle

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Abstract

Unprotected S-acylated cysteine isopeptides containing α-, β- or γ-amino acid units have been synthesized, and their conversion to native hexapeptides by S- to the N-terminus ligations involving 17-, 18- and 19-membered cyclic transition states have been demonstrated both experimentally and computationally to be more favorable than intermolecular cross-ligations.

Original languageEnglish (US)
Pages (from-to)821-7
Number of pages7
JournalChemical Biology and Drug Design
Volume80
Issue number6
DOIs
StatePublished - Dec 2012

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Cysteine
Ligation
Amino Acids

Keywords

  • Cysteine
  • Molecular Conformation
  • Nitrogen
  • Peptides
  • Sulfur
  • Journal Article
  • Research Support, Non-U.S. Gov't

Cite this

Study of chemical ligation via 17-, 18- and 19-membered cyclic transition states. / Panda, Siva S.

In: Chemical Biology and Drug Design, Vol. 80, No. 6, 12.2012, p. 821-7.

Research output: Contribution to journalArticle

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KW - Molecular Conformation

KW - Nitrogen

KW - Peptides

KW - Sulfur

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