Study of HLA system in a Mataco population: A geographically isolated American Indian tribe

C. M. VULLO, Esteban Celis, H. M. SERRA, C. M. RIERA

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A search for antigens of the HLA system has been carried out in 53 Mataco Indians of Argentina living in a geographically isolated area in the northeast of the country. Samples were mostly collected from adults of both sexes who were not directly related. Lymphocyte typing was performed using the microcytotoxicity technique of NIH. 118 sera specific for 15 antigens of the first HLA locus, 22 antigens of the second and 6 of the third were used. The most frequently found alleles were HLA‐A28, Aw31 and A2 for the first locus; B15 and B40 for the second; and Cw3 and Cw4 for the third. In addition to previously published investigations on South American Indians, our typing work shows a remarkable homogeneous gene pool and a restricted range of polymorphism; therefore, a further set of haplotypes rendered us also restricted. The most frequent haplotypes that showed a significant statistical linkage desequilibrium were: A2‐Cw4, A28‐Bx, A2‐Cw3, Aw31‐Bw16, Aw24‐Cw3, B15‐Cw3, Bw16‐Cw3 and A28‐B5. Some of these haplotypes have also been found in other indian populations.

Original languageEnglish (US)
Pages (from-to)33-40
Number of pages8
JournalTissue Antigens
Volume23
Issue number1
DOIs
StatePublished - Jan 1 1984

Fingerprint

North American Indians
Population Groups
Haplotypes
Antigens
HLA-A Antigens
Lymphocytes
South American Indians
Polymorphism
Population
Gene Pool
Genes
Argentina
HLA Antigens
varespladib methyl
Alleles
Serum

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

Cite this

Study of HLA system in a Mataco population : A geographically isolated American Indian tribe. / VULLO, C. M.; Celis, Esteban; SERRA, H. M.; RIERA, C. M.

In: Tissue Antigens, Vol. 23, No. 1, 01.01.1984, p. 33-40.

Research output: Contribution to journalArticle

VULLO, C. M. ; Celis, Esteban ; SERRA, H. M. ; RIERA, C. M. / Study of HLA system in a Mataco population : A geographically isolated American Indian tribe. In: Tissue Antigens. 1984 ; Vol. 23, No. 1. pp. 33-40.
@article{b4d1633a56694b0ea0df7c33ae20d7e0,
title = "Study of HLA system in a Mataco population: A geographically isolated American Indian tribe",
abstract = "A search for antigens of the HLA system has been carried out in 53 Mataco Indians of Argentina living in a geographically isolated area in the northeast of the country. Samples were mostly collected from adults of both sexes who were not directly related. Lymphocyte typing was performed using the microcytotoxicity technique of NIH. 118 sera specific for 15 antigens of the first HLA locus, 22 antigens of the second and 6 of the third were used. The most frequently found alleles were HLA‐A28, Aw31 and A2 for the first locus; B15 and B40 for the second; and Cw3 and Cw4 for the third. In addition to previously published investigations on South American Indians, our typing work shows a remarkable homogeneous gene pool and a restricted range of polymorphism; therefore, a further set of haplotypes rendered us also restricted. The most frequent haplotypes that showed a significant statistical linkage desequilibrium were: A2‐Cw4, A28‐Bx, A2‐Cw3, Aw31‐Bw16, Aw24‐Cw3, B15‐Cw3, Bw16‐Cw3 and A28‐B5. Some of these haplotypes have also been found in other indian populations.",
author = "VULLO, {C. M.} and Esteban Celis and SERRA, {H. M.} and RIERA, {C. M.}",
year = "1984",
month = "1",
day = "1",
doi = "10.1111/j.1399-0039.1984.tb00005.x",
language = "English (US)",
volume = "23",
pages = "33--40",
journal = "HLA",
issn = "2059-2302",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Study of HLA system in a Mataco population

T2 - A geographically isolated American Indian tribe

AU - VULLO, C. M.

AU - Celis, Esteban

AU - SERRA, H. M.

AU - RIERA, C. M.

PY - 1984/1/1

Y1 - 1984/1/1

N2 - A search for antigens of the HLA system has been carried out in 53 Mataco Indians of Argentina living in a geographically isolated area in the northeast of the country. Samples were mostly collected from adults of both sexes who were not directly related. Lymphocyte typing was performed using the microcytotoxicity technique of NIH. 118 sera specific for 15 antigens of the first HLA locus, 22 antigens of the second and 6 of the third were used. The most frequently found alleles were HLA‐A28, Aw31 and A2 for the first locus; B15 and B40 for the second; and Cw3 and Cw4 for the third. In addition to previously published investigations on South American Indians, our typing work shows a remarkable homogeneous gene pool and a restricted range of polymorphism; therefore, a further set of haplotypes rendered us also restricted. The most frequent haplotypes that showed a significant statistical linkage desequilibrium were: A2‐Cw4, A28‐Bx, A2‐Cw3, Aw31‐Bw16, Aw24‐Cw3, B15‐Cw3, Bw16‐Cw3 and A28‐B5. Some of these haplotypes have also been found in other indian populations.

AB - A search for antigens of the HLA system has been carried out in 53 Mataco Indians of Argentina living in a geographically isolated area in the northeast of the country. Samples were mostly collected from adults of both sexes who were not directly related. Lymphocyte typing was performed using the microcytotoxicity technique of NIH. 118 sera specific for 15 antigens of the first HLA locus, 22 antigens of the second and 6 of the third were used. The most frequently found alleles were HLA‐A28, Aw31 and A2 for the first locus; B15 and B40 for the second; and Cw3 and Cw4 for the third. In addition to previously published investigations on South American Indians, our typing work shows a remarkable homogeneous gene pool and a restricted range of polymorphism; therefore, a further set of haplotypes rendered us also restricted. The most frequent haplotypes that showed a significant statistical linkage desequilibrium were: A2‐Cw4, A28‐Bx, A2‐Cw3, Aw31‐Bw16, Aw24‐Cw3, B15‐Cw3, Bw16‐Cw3 and A28‐B5. Some of these haplotypes have also been found in other indian populations.

UR - http://www.scopus.com/inward/record.url?scp=0021350024&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021350024&partnerID=8YFLogxK

U2 - 10.1111/j.1399-0039.1984.tb00005.x

DO - 10.1111/j.1399-0039.1984.tb00005.x

M3 - Article

C2 - 6701886

AN - SCOPUS:0021350024

VL - 23

SP - 33

EP - 40

JO - HLA

JF - HLA

SN - 2059-2302

IS - 1

ER -