Subcellular distribution of sulfated glucuronyl glycolipids in human peripheral motor and sensory nerves

Robert K Yu, Hiide Yoshino, Masanaga Yamawaki, Jun E. Yoshino, Toshio Ariga

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Sulfated glucuronyl glycolipids (SGGL) have been implicated as important target antigens in patients with demyelinating polyneuropathy and IgM paraproteinemia. Sulfated glucuronyl paragloboside (SGPG), a major species of SGGL, was identified in the subcellular fractions of human peripheral motor and sensory nerves using a simple and quantitative method. SGPG was found to be concentrated in the myelin-enriched fractions of both motor and sensory nerves (1.3±0.3 and 1.5±0.4 μg/mg protein, respectively), whereas its concentration was 0.9±0.2 and 1.8±0.6 μg/mg protein in the axolemma-enriched fractions of motor and sensory nerves, respectively. Our finding that SGPG is more abundant in the human sensory nerve axolemma-enriched fraction may account for the clinical and pathological observations that the lesions are more heavily concentrated in the sensory nerve than in other parts of the nerve tissues in this disorder.

Original languageEnglish (US)
Pages (from-to)167-171
Number of pages5
JournalJournal of Biomedical Science
Volume1
Issue number3
DOIs
StatePublished - Jun 1 1994

Fingerprint

Glycolipids
Nerve Tissue
Paraproteinemias
Subcellular Fractions
Polyneuropathies
Myelin Sheath
Immunoglobulin M
Proteins
Tissue
Antigens
sulfoglycolipids
paragloboside

Keywords

  • Axolemma
  • HNK-1
  • IgM paraprotein
  • Motor and sensory nerve
  • Myelin
  • Polyneuropathy
  • Sulfated glucuronyl glycolipids

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

Cite this

Subcellular distribution of sulfated glucuronyl glycolipids in human peripheral motor and sensory nerves. / Yu, Robert K; Yoshino, Hiide; Yamawaki, Masanaga; Yoshino, Jun E.; Ariga, Toshio.

In: Journal of Biomedical Science, Vol. 1, No. 3, 01.06.1994, p. 167-171.

Research output: Contribution to journalArticle

Yu, Robert K ; Yoshino, Hiide ; Yamawaki, Masanaga ; Yoshino, Jun E. ; Ariga, Toshio. / Subcellular distribution of sulfated glucuronyl glycolipids in human peripheral motor and sensory nerves. In: Journal of Biomedical Science. 1994 ; Vol. 1, No. 3. pp. 167-171.
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