Abstract
Sulfated glucuronyl glycolipids (SGGL) have been implicated as important target antigens in patients with demyelinating polyneuropathy and IgM paraproteinemia. Sulfated glucuronyl paragloboside (SGPG), a major species of SGGL, was identified in the subcellular fractions of human peripheral motor and sensory nerves using a simple and quantitative method. SGPG was found to be concentrated in the myelin-enriched fractions of both motor and sensory nerves (1.3±0.3 and 1.5±0.4 μg/mg protein, respectively), whereas its concentration was 0.9±0.2 and 1.8±0.6 μg/mg protein in the axolemma-enriched fractions of motor and sensory nerves, respectively. Our finding that SGPG is more abundant in the human sensory nerve axolemma-enriched fraction may account for the clinical and pathological observations that the lesions are more heavily concentrated in the sensory nerve than in other parts of the nerve tissues in this disorder.
Original language | English (US) |
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Pages (from-to) | 167-171 |
Number of pages | 5 |
Journal | Journal of Biomedical Science |
Volume | 1 |
Issue number | 3 |
DOIs | |
State | Published - Jun 1994 |
Externally published | Yes |
Keywords
- Axolemma
- HNK-1
- IgM paraprotein
- Motor and sensory nerve
- Myelin
- Polyneuropathy
- Sulfated glucuronyl glycolipids
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Molecular Biology
- Clinical Biochemistry
- Cell Biology
- Biochemistry, medical
- Pharmacology (medical)