Subdural electrodes in focal epilepsy surgery at a typical academic epilepsy center

William O. Tatum, Jenna B. Dionisio, Fernando L. Vale

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Purpose: To assess the use of subdural intracranial EEG (iEEG) on postoperative outcomes at an epilepsy center. Methods: Ninety-one epilepsy patients underwent iEEG. Array design was compared with noninvasive EEG with over 1 year of outcome. Patient demographics, implanted brain sites, electrodes, contacts/site, and surgical location were correlated with outcome. Fisher exact test and logistics regression were used to evaluate significance (P ≤ 0.05). Results: Of ninety-one women, 55 (mean age, 32.3 years; range, 11-60) underwent tailored iEEG. Seventy of ninety-one (76.9%) resections (70% temporal) yielded 24/91 (26.4%) seizure free (SF). Strips (57.1%), grids (5.5%), or both (37.4%) for iEEG use was commonly bilateral (58.2%; 65.3% bitemporal) but did not predict outcome (P ≤ NS). A lesion (28/91) did predict a SF outcome (42.9%). The iEEG localized 45.7% of seizures beyond scalp EEG and changed the localization or lateralization in 75.7% of resected patients. Electrode design, localization, lateralization, and site of resection did not correlate with outcome (P ≤ NS). Overall, iEEG use portended a non-SF outcome (P ≤ 0.0001). Conclusions: The use of iEEG selected 46% additional patients for surgery, yet only 26% became SF. A magnetic resonance imaging lesion predicted a SF or seizure-improved outcome. Although iEEG changed the localization and lateralization of scalp ictal EEG in three quarters of patients, its use was a negative predictor for a favorable outcome. Preoperative counseling should emphasize expectations for seizure reduction in patients requiring iEEG

Original languageEnglish (US)
Pages (from-to)139-146
Number of pages8
JournalJournal of Clinical Neurophysiology
Volume32
Issue number2
DOIs
StatePublished - Apr 4 2015
Externally publishedYes

Keywords

  • EEG
  • Epilepsy
  • Intracranial
  • Invasive
  • Seizures
  • Subdural

ASJC Scopus subject areas

  • Physiology
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Subdural electrodes in focal epilepsy surgery at a typical academic epilepsy center'. Together they form a unique fingerprint.

  • Cite this