Subgroup differences in the associations between dog exposure during the first year of life and early life allergic outcomes

G. Wegienka, S. Havstad, H. Kim, E. Zoratti, Dennis Randall Ownby, K. J. Woodcroft, C. C. Johnson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The effect of dog exposure on the risk of children developing allergic disease remains controversial. Many analyses have not considered that associations may vary within population subgroups. Objective: To examine whether associations between living with a dog in the first year of life and allergic outcomes vary within subgroups selected a priori (race, gender and delivery mode). Methods: Black (n = 496) and White (n = 196) children enrolled in the WHEALS birth cohort study had a clinical examination at age 2 years to assess eczema and allergen-specific IgE (sIgE) and perform skin prick testing (SPT). Whether the child lived with an indoor dog in the first year of life was assessed through interview, as was doctor diagnosis of asthma at ages 3–6 years. Results: Living with a dog was associated with decreased odds of having ≥ 1 positive SPT (OR = 0.56, 95% CI: 0.34, 0.91) and having eczema (OR = 0.34, 95% CI: 0.20, 0.60). The association with SPT was stronger in those children born via caesarean section (c-section) vs. vaginally (OR = 0.29, 95% CI: 0.12, 0.74 vs. OR = 0.76, 95% CI: 0.43, 1.37, respectively, interaction P = 0.087) and in those who were firstborn vs. not (OR = 0.27, 95% CI: 0.11, 0.67 vs. OR = 0.82, 95% CI: 0.45, 1.47, respectively, interaction P = 0.044). The association with eczema was stronger in children born vaginally compared with those born via caesarean section (OR = 0.17, 95% CI: 0.06, 0.43 vs. OR = 0.65, 95% CI: 0.31, 1.35, respectively, interaction P = 0.025) and was stronger in Black vs. White children (OR = 0.30, 95% CI: 0.15, 0.61 vs. OR = 0.78, 95% CI: 0.29, 2.11, respectively, interaction P = 0.12). Dog keeping was not significantly inversely associated with having ≥ 1 elevated sIgE and only approached statistical significance with asthma. Conclusions and Clinical Relevance: Results likely vary between studies due to variability of specific exposure–outcome associations in subgroups defined by other factors as well as the relative distributions of those subgroups. Important allergic disorder associations will be missed without subgroup analyses.

Original languageEnglish (US)
Pages (from-to)97-105
Number of pages9
JournalClinical and Experimental Allergy
Volume47
Issue number1
DOIs
StatePublished - Jan 1 2017

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Dogs
Eczema
Cesarean Section
Skin
Immunoglobulin E
Asthma
Allergens
Cohort Studies
Parturition
Interviews
Population

Keywords

  • allergic disease
  • allergic sensitization
  • asthma
  • atopy
  • dog
  • pet
  • racial disparities

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Subgroup differences in the associations between dog exposure during the first year of life and early life allergic outcomes. / Wegienka, G.; Havstad, S.; Kim, H.; Zoratti, E.; Ownby, Dennis Randall; Woodcroft, K. J.; Johnson, C. C.

In: Clinical and Experimental Allergy, Vol. 47, No. 1, 01.01.2017, p. 97-105.

Research output: Contribution to journalArticle

Wegienka, G. ; Havstad, S. ; Kim, H. ; Zoratti, E. ; Ownby, Dennis Randall ; Woodcroft, K. J. ; Johnson, C. C. / Subgroup differences in the associations between dog exposure during the first year of life and early life allergic outcomes. In: Clinical and Experimental Allergy. 2017 ; Vol. 47, No. 1. pp. 97-105.
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abstract = "Background: The effect of dog exposure on the risk of children developing allergic disease remains controversial. Many analyses have not considered that associations may vary within population subgroups. Objective: To examine whether associations between living with a dog in the first year of life and allergic outcomes vary within subgroups selected a priori (race, gender and delivery mode). Methods: Black (n = 496) and White (n = 196) children enrolled in the WHEALS birth cohort study had a clinical examination at age 2 years to assess eczema and allergen-specific IgE (sIgE) and perform skin prick testing (SPT). Whether the child lived with an indoor dog in the first year of life was assessed through interview, as was doctor diagnosis of asthma at ages 3–6 years. Results: Living with a dog was associated with decreased odds of having ≥ 1 positive SPT (OR = 0.56, 95{\%} CI: 0.34, 0.91) and having eczema (OR = 0.34, 95{\%} CI: 0.20, 0.60). The association with SPT was stronger in those children born via caesarean section (c-section) vs. vaginally (OR = 0.29, 95{\%} CI: 0.12, 0.74 vs. OR = 0.76, 95{\%} CI: 0.43, 1.37, respectively, interaction P = 0.087) and in those who were firstborn vs. not (OR = 0.27, 95{\%} CI: 0.11, 0.67 vs. OR = 0.82, 95{\%} CI: 0.45, 1.47, respectively, interaction P = 0.044). The association with eczema was stronger in children born vaginally compared with those born via caesarean section (OR = 0.17, 95{\%} CI: 0.06, 0.43 vs. OR = 0.65, 95{\%} CI: 0.31, 1.35, respectively, interaction P = 0.025) and was stronger in Black vs. White children (OR = 0.30, 95{\%} CI: 0.15, 0.61 vs. OR = 0.78, 95{\%} CI: 0.29, 2.11, respectively, interaction P = 0.12). Dog keeping was not significantly inversely associated with having ≥ 1 elevated sIgE and only approached statistical significance with asthma. Conclusions and Clinical Relevance: Results likely vary between studies due to variability of specific exposure–outcome associations in subgroups defined by other factors as well as the relative distributions of those subgroups. Important allergic disorder associations will be missed without subgroup analyses.",
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AU - Wegienka, G.

AU - Havstad, S.

AU - Kim, H.

AU - Zoratti, E.

AU - Ownby, Dennis Randall

AU - Woodcroft, K. J.

AU - Johnson, C. C.

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N2 - Background: The effect of dog exposure on the risk of children developing allergic disease remains controversial. Many analyses have not considered that associations may vary within population subgroups. Objective: To examine whether associations between living with a dog in the first year of life and allergic outcomes vary within subgroups selected a priori (race, gender and delivery mode). Methods: Black (n = 496) and White (n = 196) children enrolled in the WHEALS birth cohort study had a clinical examination at age 2 years to assess eczema and allergen-specific IgE (sIgE) and perform skin prick testing (SPT). Whether the child lived with an indoor dog in the first year of life was assessed through interview, as was doctor diagnosis of asthma at ages 3–6 years. Results: Living with a dog was associated with decreased odds of having ≥ 1 positive SPT (OR = 0.56, 95% CI: 0.34, 0.91) and having eczema (OR = 0.34, 95% CI: 0.20, 0.60). The association with SPT was stronger in those children born via caesarean section (c-section) vs. vaginally (OR = 0.29, 95% CI: 0.12, 0.74 vs. OR = 0.76, 95% CI: 0.43, 1.37, respectively, interaction P = 0.087) and in those who were firstborn vs. not (OR = 0.27, 95% CI: 0.11, 0.67 vs. OR = 0.82, 95% CI: 0.45, 1.47, respectively, interaction P = 0.044). The association with eczema was stronger in children born vaginally compared with those born via caesarean section (OR = 0.17, 95% CI: 0.06, 0.43 vs. OR = 0.65, 95% CI: 0.31, 1.35, respectively, interaction P = 0.025) and was stronger in Black vs. White children (OR = 0.30, 95% CI: 0.15, 0.61 vs. OR = 0.78, 95% CI: 0.29, 2.11, respectively, interaction P = 0.12). Dog keeping was not significantly inversely associated with having ≥ 1 elevated sIgE and only approached statistical significance with asthma. Conclusions and Clinical Relevance: Results likely vary between studies due to variability of specific exposure–outcome associations in subgroups defined by other factors as well as the relative distributions of those subgroups. Important allergic disorder associations will be missed without subgroup analyses.

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