Subjective perception of cognition is related to mood and not performance

S. E. Marino, K. J. Meador, D. W. Loring, M. S. Okun, H. H. Fernandez, A. J. Fessler, R. P. Kustra, J. M. Miller, Patty G Ray, A. Roy, M. R. Schoenberg, V. J. Vahle, M. A. Werz

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Objective: Clinicians monitor cognitive effects of drugs primarily by asking patients to describe their side effects. We examined the relationship of subjective perception of cognition to mood and objective cognitive performance in healthy volunteers and neurological patients. Methods: Three separate experiments used healthy adults treated with lamotrigine (LTG) and topiramate (TPM), adults with epilepsy on LTG or TPM, and patients with idiopathic Parkinson's disease. Correlations were calculated for change scores on and off drugs in the first two experiments and for the single assessment in Experiment 3. Results: Across all three experiments, significant correlations were more frequent (χ2 = 259, P ≤ 0.000) for mood versus subjective cognitive perception (59%) compared with subjective versus objective cognition (2%) and mood versus objective cognitive performance (2%). Conclusions: Subjective perception of cognitive effects is related more to mood than objective performance. Clinicians should be aware of this relationship when assessing patients' cognitive complaints.

Original languageEnglish (US)
Pages (from-to)459-464
Number of pages6
JournalEpilepsy and Behavior
Volume14
Issue number3
DOIs
StatePublished - Mar 1 2009

Fingerprint

Cognition
Pharmaceutical Preparations
Parkinson Disease
Epilepsy
Healthy Volunteers
topiramate
lamotrigine

Keywords

  • Antiepileptic drugs
  • Cognition
  • Depression
  • Neuropsychological assessment
  • Parkinson's disease
  • Quality of life

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

Cite this

Marino, S. E., Meador, K. J., Loring, D. W., Okun, M. S., Fernandez, H. H., Fessler, A. J., ... Werz, M. A. (2009). Subjective perception of cognition is related to mood and not performance. Epilepsy and Behavior, 14(3), 459-464. https://doi.org/10.1016/j.yebeh.2008.12.007

Subjective perception of cognition is related to mood and not performance. / Marino, S. E.; Meador, K. J.; Loring, D. W.; Okun, M. S.; Fernandez, H. H.; Fessler, A. J.; Kustra, R. P.; Miller, J. M.; Ray, Patty G; Roy, A.; Schoenberg, M. R.; Vahle, V. J.; Werz, M. A.

In: Epilepsy and Behavior, Vol. 14, No. 3, 01.03.2009, p. 459-464.

Research output: Contribution to journalArticle

Marino, SE, Meador, KJ, Loring, DW, Okun, MS, Fernandez, HH, Fessler, AJ, Kustra, RP, Miller, JM, Ray, PG, Roy, A, Schoenberg, MR, Vahle, VJ & Werz, MA 2009, 'Subjective perception of cognition is related to mood and not performance', Epilepsy and Behavior, vol. 14, no. 3, pp. 459-464. https://doi.org/10.1016/j.yebeh.2008.12.007
Marino SE, Meador KJ, Loring DW, Okun MS, Fernandez HH, Fessler AJ et al. Subjective perception of cognition is related to mood and not performance. Epilepsy and Behavior. 2009 Mar 1;14(3):459-464. https://doi.org/10.1016/j.yebeh.2008.12.007
Marino, S. E. ; Meador, K. J. ; Loring, D. W. ; Okun, M. S. ; Fernandez, H. H. ; Fessler, A. J. ; Kustra, R. P. ; Miller, J. M. ; Ray, Patty G ; Roy, A. ; Schoenberg, M. R. ; Vahle, V. J. ; Werz, M. A. / Subjective perception of cognition is related to mood and not performance. In: Epilepsy and Behavior. 2009 ; Vol. 14, No. 3. pp. 459-464.
@article{613e414acaf3471baebc2936b179caa0,
title = "Subjective perception of cognition is related to mood and not performance",
abstract = "Objective: Clinicians monitor cognitive effects of drugs primarily by asking patients to describe their side effects. We examined the relationship of subjective perception of cognition to mood and objective cognitive performance in healthy volunteers and neurological patients. Methods: Three separate experiments used healthy adults treated with lamotrigine (LTG) and topiramate (TPM), adults with epilepsy on LTG or TPM, and patients with idiopathic Parkinson's disease. Correlations were calculated for change scores on and off drugs in the first two experiments and for the single assessment in Experiment 3. Results: Across all three experiments, significant correlations were more frequent (χ2 = 259, P ≤ 0.000) for mood versus subjective cognitive perception (59{\%}) compared with subjective versus objective cognition (2{\%}) and mood versus objective cognitive performance (2{\%}). Conclusions: Subjective perception of cognitive effects is related more to mood than objective performance. Clinicians should be aware of this relationship when assessing patients' cognitive complaints.",
keywords = "Antiepileptic drugs, Cognition, Depression, Neuropsychological assessment, Parkinson's disease, Quality of life",
author = "Marino, {S. E.} and Meador, {K. J.} and Loring, {D. W.} and Okun, {M. S.} and Fernandez, {H. H.} and Fessler, {A. J.} and Kustra, {R. P.} and Miller, {J. M.} and Ray, {Patty G} and A. Roy and Schoenberg, {M. R.} and Vahle, {V. J.} and Werz, {M. A.}",
year = "2009",
month = "3",
day = "1",
doi = "10.1016/j.yebeh.2008.12.007",
language = "English (US)",
volume = "14",
pages = "459--464",
journal = "Epilepsy and Behavior",
issn = "1525-5050",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Subjective perception of cognition is related to mood and not performance

AU - Marino, S. E.

AU - Meador, K. J.

AU - Loring, D. W.

AU - Okun, M. S.

AU - Fernandez, H. H.

AU - Fessler, A. J.

AU - Kustra, R. P.

AU - Miller, J. M.

AU - Ray, Patty G

AU - Roy, A.

AU - Schoenberg, M. R.

AU - Vahle, V. J.

AU - Werz, M. A.

PY - 2009/3/1

Y1 - 2009/3/1

N2 - Objective: Clinicians monitor cognitive effects of drugs primarily by asking patients to describe their side effects. We examined the relationship of subjective perception of cognition to mood and objective cognitive performance in healthy volunteers and neurological patients. Methods: Three separate experiments used healthy adults treated with lamotrigine (LTG) and topiramate (TPM), adults with epilepsy on LTG or TPM, and patients with idiopathic Parkinson's disease. Correlations were calculated for change scores on and off drugs in the first two experiments and for the single assessment in Experiment 3. Results: Across all three experiments, significant correlations were more frequent (χ2 = 259, P ≤ 0.000) for mood versus subjective cognitive perception (59%) compared with subjective versus objective cognition (2%) and mood versus objective cognitive performance (2%). Conclusions: Subjective perception of cognitive effects is related more to mood than objective performance. Clinicians should be aware of this relationship when assessing patients' cognitive complaints.

AB - Objective: Clinicians monitor cognitive effects of drugs primarily by asking patients to describe their side effects. We examined the relationship of subjective perception of cognition to mood and objective cognitive performance in healthy volunteers and neurological patients. Methods: Three separate experiments used healthy adults treated with lamotrigine (LTG) and topiramate (TPM), adults with epilepsy on LTG or TPM, and patients with idiopathic Parkinson's disease. Correlations were calculated for change scores on and off drugs in the first two experiments and for the single assessment in Experiment 3. Results: Across all three experiments, significant correlations were more frequent (χ2 = 259, P ≤ 0.000) for mood versus subjective cognitive perception (59%) compared with subjective versus objective cognition (2%) and mood versus objective cognitive performance (2%). Conclusions: Subjective perception of cognitive effects is related more to mood than objective performance. Clinicians should be aware of this relationship when assessing patients' cognitive complaints.

KW - Antiepileptic drugs

KW - Cognition

KW - Depression

KW - Neuropsychological assessment

KW - Parkinson's disease

KW - Quality of life

UR - http://www.scopus.com/inward/record.url?scp=63049104216&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=63049104216&partnerID=8YFLogxK

U2 - 10.1016/j.yebeh.2008.12.007

DO - 10.1016/j.yebeh.2008.12.007

M3 - Article

VL - 14

SP - 459

EP - 464

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

SN - 1525-5050

IS - 3

ER -