Submandibular gland and caries susceptibility in the obese Zucker rat

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Obesity is a prevalent disorder characterized as marked insulin resistance and low grade inflammation. We tested the hypothesis that obesity upregulates inflammatory markers in the submandibular gland in association with derangements of its architecture and pre-disposition to caries in obese Zucker rats (OZR). We also examined the potential impact of chromium picolinate (Cr(Pic)3), a nutritional supplement suggested to improve glycemic control, on the aforementioned parameters. Design: Male OZR were treated with diets lacking and containing 5 or 10mg/kg chromium (as Cr(Pic)3) from 6weeks to about 6months of age; lean Zucker rats (LZR) served as controls. Thereafter, glycemic status, salivary tissue architecture, and the levels of several inflammatory markers were determined in association with caries susceptibility. Results: OZR showed reduced insulin sensitivity, increased ratio of phospho-nuclear factor-kappa B (NF-κB) to total NF-κB, and increased intercellular adhesion molecule-1 level but similar histological features compared to LZR. Importantly, compared to LZR, OZR displayed rampant caries and a tendency for reduced dentin mineral density. Treatment of OZR with Cr(Pic)3 attenuated upregulation of these proinflammatory indicators in association with reduced severity of caries without improving insulin sensitivity. Conclusions: Obesity promotes proinflammatory changes within the submandibular gland, without affecting glandular architecture, in association with rampant caries; Cr(Pic)3 treatment provided some protective effects.

Original languageEnglish (US)
Pages (from-to)194-200
Number of pages7
JournalJournal of Oral Pathology and Medicine
Volume40
Issue number2
DOIs
StatePublished - Feb 1 2011

Fingerprint

Zucker Rats
Submandibular Gland
Insulin Resistance
Obesity
NF-kappa B
Up-Regulation
Chromium
Dentin
Intercellular Adhesion Molecule-1
Minerals
Diet
Inflammation
picolinic acid

Keywords

  • Caries
  • Cell adhesion molecules
  • Chromium picolinate
  • NF-κB
  • Submandibular gland
  • Zucker rat

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

Cite this

Submandibular gland and caries susceptibility in the obese Zucker rat. / Mozaffari, Mahmood S; Abdelsayed, Rafik A; Zakhary, Ibrahim; Elsalanty, Mohammed Elsayed; Liu, Jun Yao; Wimborne, Hereward; Elmarakby, Ahmed Abdelrazik.

In: Journal of Oral Pathology and Medicine, Vol. 40, No. 2, 01.02.2011, p. 194-200.

Research output: Contribution to journalArticle

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