Substance use and psychosocial functioning in schizophrenia among new enrollees in the NIMH CATIE study

Marvin S. Swartz, H. Ryan Wagner, Jeffrey W. Swanson, T. Scott Stroup, Joseph Patrick McEvoy, Mark McGee, Del D. Miller, Fred Reimherr, Ahsan Khan, José M. Cañive, Jeffrey A. Lieberman

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Objective: This study examined the relationship between substance use and psychosocial functioning in schizophrenia. Methods: Participants were enrolled in the Clinical Antipsychotic Trials of Intervention Effectiveness. This study used baseline assessments and examined psychosocial functioning assessed by the Quality of Life Scale. Participants were classified as being abstinent, using substances, or having a substance use disorder. Results: Of the 1,460 participants, 23 percent used substances and 37 percent had a substance use disorder. Of the 544 with a substance use disorder, 87 percent used alcohol, 44 percent used marijuana, and 36 percent used cocaine. Compared with participants who used substances, those with a substance use disorder had higher rates of polysubstance use. Compared with those who were abstinent, those who used substances had higher overall psychosocial functioning, and those with a substance use disorder had similar overall functioning but lower scores on the common objects and activities subscales. Among participants with a substance use disorder, those who used cocaine had lower overall functioning. Conclusions: Compared with abstinence, substance use and substance use disorder, unless they involved cocaine use, were generally associated with higher or equivalent overall psychosocial functioning. Patterns of substance use were similar to those in the community, suggesting that treatment of substance use disorders in schizophrenia should focus on reconnecting substance users to nonusing peer groups.

Original languageEnglish (US)
Pages (from-to)1110-1116
Number of pages7
JournalPsychiatric Services
Volume57
Issue number8
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

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National Institute of Mental Health (U.S.)
Substance-Related Disorders
Schizophrenia
Cocaine
Peer Group
Cannabis
Antipsychotic Agents
Alcohols
Quality of Life
Clinical Trials

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Swartz, M. S., Wagner, H. R., Swanson, J. W., Stroup, T. S., McEvoy, J. P., McGee, M., ... Lieberman, J. A. (2006). Substance use and psychosocial functioning in schizophrenia among new enrollees in the NIMH CATIE study. Psychiatric Services, 57(8), 1110-1116. https://doi.org/10.1176/ps.2006.57.8.1110

Substance use and psychosocial functioning in schizophrenia among new enrollees in the NIMH CATIE study. / Swartz, Marvin S.; Wagner, H. Ryan; Swanson, Jeffrey W.; Stroup, T. Scott; McEvoy, Joseph Patrick; McGee, Mark; Miller, Del D.; Reimherr, Fred; Khan, Ahsan; Cañive, José M.; Lieberman, Jeffrey A.

In: Psychiatric Services, Vol. 57, No. 8, 01.01.2006, p. 1110-1116.

Research output: Contribution to journalArticle

Swartz, MS, Wagner, HR, Swanson, JW, Stroup, TS, McEvoy, JP, McGee, M, Miller, DD, Reimherr, F, Khan, A, Cañive, JM & Lieberman, JA 2006, 'Substance use and psychosocial functioning in schizophrenia among new enrollees in the NIMH CATIE study', Psychiatric Services, vol. 57, no. 8, pp. 1110-1116. https://doi.org/10.1176/ps.2006.57.8.1110
Swartz, Marvin S. ; Wagner, H. Ryan ; Swanson, Jeffrey W. ; Stroup, T. Scott ; McEvoy, Joseph Patrick ; McGee, Mark ; Miller, Del D. ; Reimherr, Fred ; Khan, Ahsan ; Cañive, José M. ; Lieberman, Jeffrey A. / Substance use and psychosocial functioning in schizophrenia among new enrollees in the NIMH CATIE study. In: Psychiatric Services. 2006 ; Vol. 57, No. 8. pp. 1110-1116.
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