Substance use in persons with schizophrenia: Baseline prevalence and correlates from the NIMH CATIE study

Marvin S. Swartz, H. Ryan Wagner, Jeffrey W. Swanson, T. Scott Stroup, Joseph Patrick McEvoy, Jose M. Canive, Del D. Miller, Fred Reimherr, Mark McGee, Ahsan Khan, Richard Van Dorn, Robert A. Rosenheck, Jeffrey A. Lieberman

Research output: Contribution to journalArticle

120 Scopus citations

Abstract

This study examined baseline correlates of substance use in the NIMH Clinical Antipsychotic Trials of Intervention Effectiveness project. Approximately 60% of the sample was found to use substances, including 37% with current evidence of substance use disorders. Users (with and without substance use disorders), compared with nonusers, were significantly more likely to be male, be African-American, have lower educational attainment, have a recent period of homelessness, report more childhood conduct problems, have a history of major depression, have lower negative symptom and higher positive symptom scores on the Positive and Negative Syndrome Scale, and have a recent illness exacerbation. Individuals with comorbid substance use disorders were significantly more likely to be male, report more childhood conduct problems, have higher positive symptom scores on the Positive and Negative Syndrome Scale, and have a recent illness exacerbation. These analyses suggest that substance use disorders in schizophrenia are especially common among men with a history of childhood conduct disorder problems and that childhood conduct disorder problems are potent risk factors for substance use disorders in schizophrenia.

Original languageEnglish (US)
Pages (from-to)164-172
Number of pages9
JournalJournal of Nervous and Mental Disease
Volume194
Issue number3
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

Keywords

  • Childhood antisocial behavior
  • Schizophrenia
  • Substance abuse

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Swartz, M. S., Wagner, H. R., Swanson, J. W., Stroup, T. S., McEvoy, J. P., Canive, J. M., Miller, D. D., Reimherr, F., McGee, M., Khan, A., Van Dorn, R., Rosenheck, R. A., & Lieberman, J. A. (2006). Substance use in persons with schizophrenia: Baseline prevalence and correlates from the NIMH CATIE study. Journal of Nervous and Mental Disease, 194(3), 164-172. https://doi.org/10.1097/01.nmd.0000202575.79453.6e