Substance use in persons with schizophrenia: Baseline prevalence and correlates from the NIMH CATIE study

Marvin S. Swartz, H. Ryan Wagner, Jeffrey W. Swanson, T. Scott Stroup, Joseph Patrick McEvoy, Jose M. Canive, Del D. Miller, Fred Reimherr, Mark McGee, Ahsan Khan, Richard Van Dorn, Robert A. Rosenheck, Jeffrey A. Lieberman

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

This study examined baseline correlates of substance use in the NIMH Clinical Antipsychotic Trials of Intervention Effectiveness project. Approximately 60% of the sample was found to use substances, including 37% with current evidence of substance use disorders. Users (with and without substance use disorders), compared with nonusers, were significantly more likely to be male, be African-American, have lower educational attainment, have a recent period of homelessness, report more childhood conduct problems, have a history of major depression, have lower negative symptom and higher positive symptom scores on the Positive and Negative Syndrome Scale, and have a recent illness exacerbation. Individuals with comorbid substance use disorders were significantly more likely to be male, report more childhood conduct problems, have higher positive symptom scores on the Positive and Negative Syndrome Scale, and have a recent illness exacerbation. These analyses suggest that substance use disorders in schizophrenia are especially common among men with a history of childhood conduct disorder problems and that childhood conduct disorder problems are potent risk factors for substance use disorders in schizophrenia.

Original languageEnglish (US)
Pages (from-to)164-172
Number of pages9
JournalJournal of Nervous and Mental Disease
Volume194
Issue number3
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

Fingerprint

National Institute of Mental Health (U.S.)
Substance-Related Disorders
Schizophrenia
Conduct Disorder
Homeless Persons
African Americans
Antipsychotic Agents
Clinical Trials
Depression

Keywords

  • Childhood antisocial behavior
  • Schizophrenia
  • Substance abuse

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Substance use in persons with schizophrenia : Baseline prevalence and correlates from the NIMH CATIE study. / Swartz, Marvin S.; Wagner, H. Ryan; Swanson, Jeffrey W.; Stroup, T. Scott; McEvoy, Joseph Patrick; Canive, Jose M.; Miller, Del D.; Reimherr, Fred; McGee, Mark; Khan, Ahsan; Van Dorn, Richard; Rosenheck, Robert A.; Lieberman, Jeffrey A.

In: Journal of Nervous and Mental Disease, Vol. 194, No. 3, 01.03.2006, p. 164-172.

Research output: Contribution to journalArticle

Swartz, MS, Wagner, HR, Swanson, JW, Stroup, TS, McEvoy, JP, Canive, JM, Miller, DD, Reimherr, F, McGee, M, Khan, A, Van Dorn, R, Rosenheck, RA & Lieberman, JA 2006, 'Substance use in persons with schizophrenia: Baseline prevalence and correlates from the NIMH CATIE study', Journal of Nervous and Mental Disease, vol. 194, no. 3, pp. 164-172. https://doi.org/10.1097/01.nmd.0000202575.79453.6e
Swartz, Marvin S. ; Wagner, H. Ryan ; Swanson, Jeffrey W. ; Stroup, T. Scott ; McEvoy, Joseph Patrick ; Canive, Jose M. ; Miller, Del D. ; Reimherr, Fred ; McGee, Mark ; Khan, Ahsan ; Van Dorn, Richard ; Rosenheck, Robert A. ; Lieberman, Jeffrey A. / Substance use in persons with schizophrenia : Baseline prevalence and correlates from the NIMH CATIE study. In: Journal of Nervous and Mental Disease. 2006 ; Vol. 194, No. 3. pp. 164-172.
@article{2abb81b69f35451baf3b43db4c6a50ff,
title = "Substance use in persons with schizophrenia: Baseline prevalence and correlates from the NIMH CATIE study",
abstract = "This study examined baseline correlates of substance use in the NIMH Clinical Antipsychotic Trials of Intervention Effectiveness project. Approximately 60{\%} of the sample was found to use substances, including 37{\%} with current evidence of substance use disorders. Users (with and without substance use disorders), compared with nonusers, were significantly more likely to be male, be African-American, have lower educational attainment, have a recent period of homelessness, report more childhood conduct problems, have a history of major depression, have lower negative symptom and higher positive symptom scores on the Positive and Negative Syndrome Scale, and have a recent illness exacerbation. Individuals with comorbid substance use disorders were significantly more likely to be male, report more childhood conduct problems, have higher positive symptom scores on the Positive and Negative Syndrome Scale, and have a recent illness exacerbation. These analyses suggest that substance use disorders in schizophrenia are especially common among men with a history of childhood conduct disorder problems and that childhood conduct disorder problems are potent risk factors for substance use disorders in schizophrenia.",
keywords = "Childhood antisocial behavior, Schizophrenia, Substance abuse",
author = "Swartz, {Marvin S.} and Wagner, {H. Ryan} and Swanson, {Jeffrey W.} and Stroup, {T. Scott} and McEvoy, {Joseph Patrick} and Canive, {Jose M.} and Miller, {Del D.} and Fred Reimherr and Mark McGee and Ahsan Khan and {Van Dorn}, Richard and Rosenheck, {Robert A.} and Lieberman, {Jeffrey A.}",
year = "2006",
month = "3",
day = "1",
doi = "10.1097/01.nmd.0000202575.79453.6e",
language = "English (US)",
volume = "194",
pages = "164--172",
journal = "Journal of Nervous and Mental Disease",
issn = "0022-3018",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Substance use in persons with schizophrenia

T2 - Baseline prevalence and correlates from the NIMH CATIE study

AU - Swartz, Marvin S.

AU - Wagner, H. Ryan

AU - Swanson, Jeffrey W.

AU - Stroup, T. Scott

AU - McEvoy, Joseph Patrick

AU - Canive, Jose M.

AU - Miller, Del D.

AU - Reimherr, Fred

AU - McGee, Mark

AU - Khan, Ahsan

AU - Van Dorn, Richard

AU - Rosenheck, Robert A.

AU - Lieberman, Jeffrey A.

PY - 2006/3/1

Y1 - 2006/3/1

N2 - This study examined baseline correlates of substance use in the NIMH Clinical Antipsychotic Trials of Intervention Effectiveness project. Approximately 60% of the sample was found to use substances, including 37% with current evidence of substance use disorders. Users (with and without substance use disorders), compared with nonusers, were significantly more likely to be male, be African-American, have lower educational attainment, have a recent period of homelessness, report more childhood conduct problems, have a history of major depression, have lower negative symptom and higher positive symptom scores on the Positive and Negative Syndrome Scale, and have a recent illness exacerbation. Individuals with comorbid substance use disorders were significantly more likely to be male, report more childhood conduct problems, have higher positive symptom scores on the Positive and Negative Syndrome Scale, and have a recent illness exacerbation. These analyses suggest that substance use disorders in schizophrenia are especially common among men with a history of childhood conduct disorder problems and that childhood conduct disorder problems are potent risk factors for substance use disorders in schizophrenia.

AB - This study examined baseline correlates of substance use in the NIMH Clinical Antipsychotic Trials of Intervention Effectiveness project. Approximately 60% of the sample was found to use substances, including 37% with current evidence of substance use disorders. Users (with and without substance use disorders), compared with nonusers, were significantly more likely to be male, be African-American, have lower educational attainment, have a recent period of homelessness, report more childhood conduct problems, have a history of major depression, have lower negative symptom and higher positive symptom scores on the Positive and Negative Syndrome Scale, and have a recent illness exacerbation. Individuals with comorbid substance use disorders were significantly more likely to be male, report more childhood conduct problems, have higher positive symptom scores on the Positive and Negative Syndrome Scale, and have a recent illness exacerbation. These analyses suggest that substance use disorders in schizophrenia are especially common among men with a history of childhood conduct disorder problems and that childhood conduct disorder problems are potent risk factors for substance use disorders in schizophrenia.

KW - Childhood antisocial behavior

KW - Schizophrenia

KW - Substance abuse

UR - http://www.scopus.com/inward/record.url?scp=33645104040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645104040&partnerID=8YFLogxK

U2 - 10.1097/01.nmd.0000202575.79453.6e

DO - 10.1097/01.nmd.0000202575.79453.6e

M3 - Article

C2 - 16534433

AN - SCOPUS:33645104040

VL - 194

SP - 164

EP - 172

JO - Journal of Nervous and Mental Disease

JF - Journal of Nervous and Mental Disease

SN - 0022-3018

IS - 3

ER -