Subtleties of biomineralisation revealed by manipulation of the eggshell membrane

Nan Li, Li na Niu, Yi pin Qi, Cynthia K.Y. Yiu, Heonjune Ryou, Dwayne D. Arola, Ji hua Chen, David Henry Pashley, Franklin Chi Meng Tay

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Biocalcification of collagen matrices with calcium phosphate and biosilicification of diatom frustules with amorphous silica are two discrete processes that have intrigued biologists and materials scientists for decades. Recent advancements in the understanding of the mechanisms involved in these two biomineralisation processes have resulted in the use of biomimetic strategies to replicate these processes separately using polyanionic, polycationic or zwitterionic analogues of extracellular matrix proteins to stabilise amorphous mineral precursor phases. To date, there is a lack of a universal model that enables the subtleties of these two apparently dissimilar biomineralisation processes to be studied together. Here, we utilise the eggshell membrane as a universal model for differential biomimetic calcification and silicification. By manipulating the eggshell membrane to render it permeable to stabilised mineral precursors, it is possible to introduce nanostructured calcium phosphate or silica into eggshell membrane fibre cores or mantles. We provide a model for infiltrating the two compartmental niches of a biopolymer membrane with different intrafibre minerals to obtain materials with potentially improved structure-property relationships.

Original languageEnglish (US)
Pages (from-to)8743-8752
Number of pages10
JournalBiomaterials
Volume32
Issue number34
DOIs
StatePublished - Dec 1 2011

Fingerprint

Egg Shell
Biomineralization
Membranes
Minerals
Biomimetics
Calcium phosphate
Silicon Dioxide
Silica
Diatoms
Biopolymers
Extracellular Matrix Proteins
Collagen
Proteins
Fibers
calcium phosphate

Keywords

  • Apatite
  • Biomineralisation
  • Membrane
  • Silica

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Subtleties of biomineralisation revealed by manipulation of the eggshell membrane. / Li, Nan; Niu, Li na; Qi, Yi pin; Yiu, Cynthia K.Y.; Ryou, Heonjune; Arola, Dwayne D.; Chen, Ji hua; Pashley, David Henry; Tay, Franklin Chi Meng.

In: Biomaterials, Vol. 32, No. 34, 01.12.2011, p. 8743-8752.

Research output: Contribution to journalArticle

Li, N, Niu, LN, Qi, YP, Yiu, CKY, Ryou, H, Arola, DD, Chen, JH, Pashley, DH & Tay, FCM 2011, 'Subtleties of biomineralisation revealed by manipulation of the eggshell membrane', Biomaterials, vol. 32, no. 34, pp. 8743-8752. https://doi.org/10.1016/j.biomaterials.2011.08.007
Li, Nan ; Niu, Li na ; Qi, Yi pin ; Yiu, Cynthia K.Y. ; Ryou, Heonjune ; Arola, Dwayne D. ; Chen, Ji hua ; Pashley, David Henry ; Tay, Franklin Chi Meng. / Subtleties of biomineralisation revealed by manipulation of the eggshell membrane. In: Biomaterials. 2011 ; Vol. 32, No. 34. pp. 8743-8752.
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