Background: SAP102 is a scaffolding protein that regulates NMDA receptor function. Results: Specific SAP102 spliced isoform is enriched at synapses to regulate NMDA receptor surface expression. Conclusion: I2 region-containing SAP102 is required for the regulation of subunit-specificNMDAreceptor surface expression.Significance: This is the first study showing that SAP102 synaptic targeting is critical for regulating NMDAreceptor trafficking.
|Original language||English (US)|
|Number of pages||12|
|Journal||Journal of Biological Chemistry|
|State||Published - Feb 20 2015|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology