Subunit-specific Regulation of N-Methyl-D-aspartate (NMDA) Receptor Trafficking by SAP102 Protein Splice Variants

Zhe Wei, Blake Behrman, Wei-Hua Wu, Bo-Shiun Chen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: SAP102 is a scaffolding protein that regulates NMDA receptor function. Results: Specific SAP102 spliced isoform is enriched at synapses to regulate NMDA receptor surface expression. Conclusion: I2 region-containing SAP102 is required for the regulation of subunit-specificNMDAreceptor surface expression.Significance: This is the first study showing that SAP102 synaptic targeting is critical for regulating NMDAreceptor trafficking.

Original languageEnglish (US)
Pages (from-to)5105-5116
Number of pages12
JournalJournal of Biological Chemistry
Volume290
Issue number8
DOIs
StatePublished - Feb 20 2015

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N-Methyl-D-Aspartate Receptors
Protein Isoforms
Synapses
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Subunit-specific Regulation of N-Methyl-D-aspartate (NMDA) Receptor Trafficking by SAP102 Protein Splice Variants. / Wei, Zhe; Behrman, Blake; Wu, Wei-Hua; Chen, Bo-Shiun.

In: Journal of Biological Chemistry, Vol. 290, No. 8, 20.02.2015, p. 5105-5116.

Research output: Contribution to journalArticle

Wei, Zhe ; Behrman, Blake ; Wu, Wei-Hua ; Chen, Bo-Shiun. / Subunit-specific Regulation of N-Methyl-D-aspartate (NMDA) Receptor Trafficking by SAP102 Protein Splice Variants. In: Journal of Biological Chemistry. 2015 ; Vol. 290, No. 8. pp. 5105-5116.
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