Subunit-specific Regulation of N-Methyl-D-aspartate (NMDA) Receptor Trafficking by SAP102 Protein Splice Variants

Zhe Wei, Blake Behrman, Wei Hua Wu, Bo Shiun Chen

Research output: Contribution to journalArticle

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Abstract

Background: SAP102 is a scaffolding protein that regulates NMDA receptor function. Results: Specific SAP102 spliced isoform is enriched at synapses to regulate NMDA receptor surface expression. Conclusion: I2 region-containing SAP102 is required for the regulation of subunit-specificNMDAreceptor surface expression.Significance: This is the first study showing that SAP102 synaptic targeting is critical for regulating NMDAreceptor trafficking.

Original languageEnglish (US)
Pages (from-to)5105-5116
Number of pages12
JournalJournal of Biological Chemistry
Volume290
Issue number8
DOIs
StatePublished - Feb 20 2015

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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