Subunit-specific Regulation of N-Methyl-D-aspartate (NMDA) Receptor Trafficking by SAP102 Protein Splice Variants

Zhe Wei; Blake Behrman; Wei Hua Wu; Bo Shiun Chen

doi:10.1074/jbc.M114.599969

Subunit-specific Regulation of N-Methyl-D-aspartate (NMDA) Receptor Trafficking by SAP102 Protein Splice Variants

Zhe Wei, Blake Behrman, Wei Hua Wu, Bo Shiun Chen

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Background: SAP102 is a scaffolding protein that regulates NMDA receptor function. Results: Specific SAP102 spliced isoform is enriched at synapses to regulate NMDA receptor surface expression. Conclusion: I2 region-containing SAP102 is required for the regulation of subunit-specificNMDAreceptor surface expression.Significance: This is the first study showing that SAP102 synaptic targeting is critical for regulating NMDAreceptor trafficking.

Original language	English (US)
Pages (from-to)	5105-5116
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	290
Issue number	8
DOIs	https://doi.org/10.1074/jbc.M114.599969
State	Published - Feb 20 2015

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M114.599969

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abstract = "Background: SAP102 is a scaffolding protein that regulates NMDA receptor function. Results: Specific SAP102 spliced isoform is enriched at synapses to regulate NMDA receptor surface expression. Conclusion: I2 region-containing SAP102 is required for the regulation of subunit-specificNMDAreceptor surface expression.Significance: This is the first study showing that SAP102 synaptic targeting is critical for regulating NMDAreceptor trafficking.",

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AU - Chen, Bo Shiun

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AB - Background: SAP102 is a scaffolding protein that regulates NMDA receptor function. Results: Specific SAP102 spliced isoform is enriched at synapses to regulate NMDA receptor surface expression. Conclusion: I2 region-containing SAP102 is required for the regulation of subunit-specificNMDAreceptor surface expression.Significance: This is the first study showing that SAP102 synaptic targeting is critical for regulating NMDAreceptor trafficking.

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Subunit-specific Regulation of N-Methyl-D-aspartate (NMDA) Receptor Trafficking by SAP102 Protein Splice Variants

Abstract

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