Successful MDR-TB treatment regimens including Amikacin are associated with high rates of hearing loss

Chawangwa Modongo, Rafal S. Sobota, Boikobo Kesenogile, Ronald Ncube, Giorgio Sirugo, Scott M. Williams, Nicola M. Zetola

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Background: Aminoglycosides are a critical component of multidrug-resistant tuberculosis (MDR-TB) treatment but data on their efficacy and adverse effects in Botswana is scarce. We determined the effect of amikacin on treatment outcomes and development of hearing loss in MDR-TB patients. Methods: Patients started on MDR-TB treatment between 2006 and 2012 were included. Multivariate analysis was used to determine the effect of amikacin on treatment outcomes and development of hearing loss. Results: 437 MDR-TB patients were included, 288 (66%) of whom were HIV co-infected. 270 (62%) developed hearing loss, of whom 147 (54%) had audiometry. Of the 313 (72%) patients who completed treatment, 228 (73%) had a good outcome (cure or treatment completion). Good outcome was associated with longer amikacin treatment (adjusted OR [aOR] 1.13, 95% CI 1.06 - 1.21) and higher dosage (aOR 1.90, 95% CI 1.12 - 2.99). Longer amikacin duration (aOR 1.98, 95% CI 1.86 - 2.12) and higher dosage per weight per month (aOR 1.15, 95% CI 1.04 - 1.28) were associated with development of hearing loss. Amikacin treatment duration modified the effect of the dosage on the risk of hearing loss, increasing this risk as the duration increased. Conclusions: Amikacin was effective for MDR-TB treatment, but was associated with a high incidence of hearing loss especially in our study population. Total treatment duration and average monthly amikacin dose were associated with improved outcomes; however these were also associated with development of hearing loss.

Original languageEnglish (US)
Article number542
JournalBMC Infectious Diseases
Volume14
Issue number1
DOIs
StatePublished - Oct 9 2014
Externally publishedYes

Keywords

  • Amikacin
  • Aminoglycosides
  • Hearing loss
  • HIV
  • Multi-drug resistant tuberculosis

ASJC Scopus subject areas

  • Infectious Diseases

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