SUMO wrestling with type 1 diabetes

Manyu Li, Dehuang Guo, Carlos M. Isales, Decio L. Eizirik, Mark Atkinson, Jin Xiong She, Cong Yi Wang

Research output: Contribution to journalReview article

70 Scopus citations

Abstract

Post-translational modification of proteins by phosphorylation, methylation, acetylation, or ubiquitylation represent central mechanisms through which various biological processes are regulated. Reversible covalent modification (i.e., sumoylation) of proteins by the small ubiquitin-like modifier (SUMO) has also emerged as an important mechanism contributing to the dynamic regulation of protein function. Sumoylation has been linked to the pathogenesis of a variety of disorders including Alzheimer's disease (AD), Huntington's disease (HD), and type 1 diabetes (T1D). Advances in our understanding of the role of sumoylation suggested a novel regulatory mechanism for the regulation of immune responsive gene expression. In this review, we first update recent advances in the field of sumoylation, then specifically evaluate its regulatory role in several key signaling pathways for immune response and discuss its possible implication in T1D pathogenesis.

Original languageEnglish (US)
Pages (from-to)504-513
Number of pages10
JournalJournal of Molecular Medicine
Volume83
Issue number7
DOIs
StatePublished - Jul 1 2005

Keywords

  • Autoimmunity
  • Immune
  • Regulation
  • SUMO
  • Sumoylation
  • Transcription

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Genetics(clinical)

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    Li, M., Guo, D., Isales, C. M., Eizirik, D. L., Atkinson, M., She, J. X., & Wang, C. Y. (2005). SUMO wrestling with type 1 diabetes. Journal of Molecular Medicine, 83(7), 504-513. https://doi.org/10.1007/s00109-005-0645-5