[18F]2-fluoro-2-deoxyglucose positron emission tomography/ computed tomography in predicting radiation pneumonitis

Hao Song, Jin Ming Yu, Feng Ming Kong, Jie Lu, Tong Bai, Li Ma, Zheng Fu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Prevention is presently the only available method to limit radiation-induced lung morbidity. A good predictor is the key point of prevention. This study aimed to investigate if [18F]2-fluoro-2-deoxyglucose (FDG) uptake changes in the lung after radiotherapy could be used as a new predictor for acute radiation pneumonitis (RP). Methods: Forty-one patients with lung cancer underwent FDG positron emission tomography /computed tomography (FDG-PET/CT) imaging before and after radiotherapy. The mean standardized uptake value (SUV) was measured for the isodose regions of 0-9 Gy, 10-19 Gy, 20-29 Gy, 30-39 Gy, 40-49 Gy. The mean SUV of these regions after radiotherapy was compared with baseline. The mean SUV in patients who developed RP was also compared with that in those who did not. The statistical difference was determined by matched pair t test. The Radiation Therapy Oncology Group (RTOG) criteria were used for diagnosis and grading of RP. Results: With a median follow-up of 12 months, 11 (26.8%) of the 41 patients developed grade 2 and above acute RP. The mean SUV of regions (10-19 Gy, 20-29 Gy, 30-39 Gy, 40-49 Gy) increased after radiation therapy in all 41 patients. The mean SUVs after radiation therapy were 0.54, 0.68, 1.31, 1.74 and 2.27 for 0-9 Gy, 10-19 Gy, 20-29 Gy, 30-39 Gy and 40-49 Gy, respectively. Before the radiation therapy, the mean SUV in each region was 0.53, 0.52, 0.52, 0.53 and 0.54, respectively. These patients had significantly higher FDG activities in regions receiving 10 Gy or more (P <0.001). Compared with their counterparts, the elevation of SUV was significantly greater in those patients who developed acute RP subsequently. Conclusion: The mean SUV of the lung tissue may be a useful predictor for the acute RP. FDG-PET/CT may play a new role in the study of the radiation damage of the lung.

Original languageEnglish (US)
Pages (from-to)1311-1315
Number of pages5
JournalChinese Medical Journal
Volume122
Issue number11
DOIs
StatePublished - Jun 5 2009

Fingerprint

Radiation Pneumonitis
Fluorodeoxyglucose F18
Radiotherapy
Deoxyglucose
Lung
Radiation
Radiation Oncology
Positron Emission Tomography Computed Tomography
Lung Neoplasms
Morbidity

Keywords

  • [F]2-fluoro-2-deoxyglucose
  • Positron emission tomography
  • Radiation pneumonitis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

[18F]2-fluoro-2-deoxyglucose positron emission tomography/ computed tomography in predicting radiation pneumonitis. / Song, Hao; Yu, Jin Ming; Kong, Feng Ming; Lu, Jie; Bai, Tong; Ma, Li; Fu, Zheng.

In: Chinese Medical Journal, Vol. 122, No. 11, 05.06.2009, p. 1311-1315.

Research output: Contribution to journalArticle

Song, Hao ; Yu, Jin Ming ; Kong, Feng Ming ; Lu, Jie ; Bai, Tong ; Ma, Li ; Fu, Zheng. / [18F]2-fluoro-2-deoxyglucose positron emission tomography/ computed tomography in predicting radiation pneumonitis. In: Chinese Medical Journal. 2009 ; Vol. 122, No. 11. pp. 1311-1315.
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abstract = "Background: Prevention is presently the only available method to limit radiation-induced lung morbidity. A good predictor is the key point of prevention. This study aimed to investigate if [18F]2-fluoro-2-deoxyglucose (FDG) uptake changes in the lung after radiotherapy could be used as a new predictor for acute radiation pneumonitis (RP). Methods: Forty-one patients with lung cancer underwent FDG positron emission tomography /computed tomography (FDG-PET/CT) imaging before and after radiotherapy. The mean standardized uptake value (SUV) was measured for the isodose regions of 0-9 Gy, 10-19 Gy, 20-29 Gy, 30-39 Gy, 40-49 Gy. The mean SUV of these regions after radiotherapy was compared with baseline. The mean SUV in patients who developed RP was also compared with that in those who did not. The statistical difference was determined by matched pair t test. The Radiation Therapy Oncology Group (RTOG) criteria were used for diagnosis and grading of RP. Results: With a median follow-up of 12 months, 11 (26.8{\%}) of the 41 patients developed grade 2 and above acute RP. The mean SUV of regions (10-19 Gy, 20-29 Gy, 30-39 Gy, 40-49 Gy) increased after radiation therapy in all 41 patients. The mean SUVs after radiation therapy were 0.54, 0.68, 1.31, 1.74 and 2.27 for 0-9 Gy, 10-19 Gy, 20-29 Gy, 30-39 Gy and 40-49 Gy, respectively. Before the radiation therapy, the mean SUV in each region was 0.53, 0.52, 0.52, 0.53 and 0.54, respectively. These patients had significantly higher FDG activities in regions receiving 10 Gy or more (P <0.001). Compared with their counterparts, the elevation of SUV was significantly greater in those patients who developed acute RP subsequently. Conclusion: The mean SUV of the lung tissue may be a useful predictor for the acute RP. FDG-PET/CT may play a new role in the study of the radiation damage of the lung.",
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T1 - [18F]2-fluoro-2-deoxyglucose positron emission tomography/ computed tomography in predicting radiation pneumonitis

AU - Song, Hao

AU - Yu, Jin Ming

AU - Kong, Feng Ming

AU - Lu, Jie

AU - Bai, Tong

AU - Ma, Li

AU - Fu, Zheng

PY - 2009/6/5

Y1 - 2009/6/5

N2 - Background: Prevention is presently the only available method to limit radiation-induced lung morbidity. A good predictor is the key point of prevention. This study aimed to investigate if [18F]2-fluoro-2-deoxyglucose (FDG) uptake changes in the lung after radiotherapy could be used as a new predictor for acute radiation pneumonitis (RP). Methods: Forty-one patients with lung cancer underwent FDG positron emission tomography /computed tomography (FDG-PET/CT) imaging before and after radiotherapy. The mean standardized uptake value (SUV) was measured for the isodose regions of 0-9 Gy, 10-19 Gy, 20-29 Gy, 30-39 Gy, 40-49 Gy. The mean SUV of these regions after radiotherapy was compared with baseline. The mean SUV in patients who developed RP was also compared with that in those who did not. The statistical difference was determined by matched pair t test. The Radiation Therapy Oncology Group (RTOG) criteria were used for diagnosis and grading of RP. Results: With a median follow-up of 12 months, 11 (26.8%) of the 41 patients developed grade 2 and above acute RP. The mean SUV of regions (10-19 Gy, 20-29 Gy, 30-39 Gy, 40-49 Gy) increased after radiation therapy in all 41 patients. The mean SUVs after radiation therapy were 0.54, 0.68, 1.31, 1.74 and 2.27 for 0-9 Gy, 10-19 Gy, 20-29 Gy, 30-39 Gy and 40-49 Gy, respectively. Before the radiation therapy, the mean SUV in each region was 0.53, 0.52, 0.52, 0.53 and 0.54, respectively. These patients had significantly higher FDG activities in regions receiving 10 Gy or more (P <0.001). Compared with their counterparts, the elevation of SUV was significantly greater in those patients who developed acute RP subsequently. Conclusion: The mean SUV of the lung tissue may be a useful predictor for the acute RP. FDG-PET/CT may play a new role in the study of the radiation damage of the lung.

AB - Background: Prevention is presently the only available method to limit radiation-induced lung morbidity. A good predictor is the key point of prevention. This study aimed to investigate if [18F]2-fluoro-2-deoxyglucose (FDG) uptake changes in the lung after radiotherapy could be used as a new predictor for acute radiation pneumonitis (RP). Methods: Forty-one patients with lung cancer underwent FDG positron emission tomography /computed tomography (FDG-PET/CT) imaging before and after radiotherapy. The mean standardized uptake value (SUV) was measured for the isodose regions of 0-9 Gy, 10-19 Gy, 20-29 Gy, 30-39 Gy, 40-49 Gy. The mean SUV of these regions after radiotherapy was compared with baseline. The mean SUV in patients who developed RP was also compared with that in those who did not. The statistical difference was determined by matched pair t test. The Radiation Therapy Oncology Group (RTOG) criteria were used for diagnosis and grading of RP. Results: With a median follow-up of 12 months, 11 (26.8%) of the 41 patients developed grade 2 and above acute RP. The mean SUV of regions (10-19 Gy, 20-29 Gy, 30-39 Gy, 40-49 Gy) increased after radiation therapy in all 41 patients. The mean SUVs after radiation therapy were 0.54, 0.68, 1.31, 1.74 and 2.27 for 0-9 Gy, 10-19 Gy, 20-29 Gy, 30-39 Gy and 40-49 Gy, respectively. Before the radiation therapy, the mean SUV in each region was 0.53, 0.52, 0.52, 0.53 and 0.54, respectively. These patients had significantly higher FDG activities in regions receiving 10 Gy or more (P <0.001). Compared with their counterparts, the elevation of SUV was significantly greater in those patients who developed acute RP subsequently. Conclusion: The mean SUV of the lung tissue may be a useful predictor for the acute RP. FDG-PET/CT may play a new role in the study of the radiation damage of the lung.

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