89Sr therapy for pain relief in patients with bone metastases

Kiyoshi Koizumi; Ali S. Arbab; Keiji Toyama; Masayo Shirasu; Sachiko Osawa; Takuji Araki; Motoshi Yamaguchi; Hiroshi Onishi; Tsutomu Araki; Takao Arai; Hideki Komatsu; Akira Ueno; Hisashi Nokata

⁸⁹Sr therapy for pain relief in patients with bone metastases

Kiyoshi Koizumi, Ali S. Arbab, Keiji Toyama, Masayo Shirasu, Sachiko Osawa, Takuji Araki, Motoshi Yamaguchi, Hiroshi Onishi, Tsutomu Araki, Takao Arai, Hideki Komatsu, Akira Ueno, Hisashi Nokata

Biochemistry and Molecular Biology

Research output: Contribution to journal › Article

Abstract

Radioactive strontium chloride ( ⁸⁹Sr) was administered for pain relief in 6 patients with bone metastases (4 prostate cancer and 2 breast cancer patients). Out of 6 patients, 2 showed apparent relief of bone pain and improvement of QOL, and 3 showed slight relief of the pain with or without improvement of QOL; that is, 83% was effective. Side effects were seen in 2 patients; transient deterioration of bone pain in one patient and bone marrow suppression in the other patient. The patient who showed bone marrow suppression had rather more lesions of bone metastasis (diffuse metastasis) and least urinary excretion of the radioactivity. Urinary excretion for 2 days varied 5 to 40% of the administered dose and was less in the patients with more metastatic lesions.

Original language	English (US)
Pages (from-to)	1243-1248
Number of pages	6
Journal	Kakuigaku
Volume	33
Issue number	11
State	Published - 1996

Keywords

Bone metastasis
Pain relief
Radionuclide therapy
Sr

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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Koizumi, K., Arbab, A. S., Toyama, K., Shirasu, M., Osawa, S., Araki, T., Yamaguchi, M., Onishi, H., Araki, T., Arai, T., Komatsu, H., Ueno, A., & Nokata, H. (1996). ⁸⁹Sr therapy for pain relief in patients with bone metastases. Kakuigaku, 33(11), 1243-1248.

⁸⁹Sr therapy for pain relief in patients with bone metastases. / Koizumi, Kiyoshi; Arbab, Ali S.; Toyama, Keiji; Shirasu, Masayo; Osawa, Sachiko; Araki, Takuji; Yamaguchi, Motoshi; Onishi, Hiroshi; Araki, Tsutomu; Arai, Takao; Komatsu, Hideki; Ueno, Akira; Nokata, Hisashi.

In: Kakuigaku, Vol. 33, No. 11, 1996, p. 1243-1248.

Research output: Contribution to journal › Article

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abstract = "Radioactive strontium chloride ( 89Sr) was administered for pain relief in 6 patients with bone metastases (4 prostate cancer and 2 breast cancer patients). Out of 6 patients, 2 showed apparent relief of bone pain and improvement of QOL, and 3 showed slight relief of the pain with or without improvement of QOL; that is, 83% was effective. Side effects were seen in 2 patients; transient deterioration of bone pain in one patient and bone marrow suppression in the other patient. The patient who showed bone marrow suppression had rather more lesions of bone metastasis (diffuse metastasis) and least urinary excretion of the radioactivity. Urinary excretion for 2 days varied 5 to 40% of the administered dose and was less in the patients with more metastatic lesions.",

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AU - Koizumi, Kiyoshi

AU - Arbab, Ali S.

AU - Toyama, Keiji

AU - Shirasu, Masayo

AU - Osawa, Sachiko

AU - Araki, Takuji

AU - Yamaguchi, Motoshi

AU - Onishi, Hiroshi

AU - Araki, Tsutomu

AU - Arai, Takao

AU - Komatsu, Hideki

AU - Ueno, Akira

AU - Nokata, Hisashi

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AB - Radioactive strontium chloride ( 89Sr) was administered for pain relief in 6 patients with bone metastases (4 prostate cancer and 2 breast cancer patients). Out of 6 patients, 2 showed apparent relief of bone pain and improvement of QOL, and 3 showed slight relief of the pain with or without improvement of QOL; that is, 83% was effective. Side effects were seen in 2 patients; transient deterioration of bone pain in one patient and bone marrow suppression in the other patient. The patient who showed bone marrow suppression had rather more lesions of bone metastasis (diffuse metastasis) and least urinary excretion of the radioactivity. Urinary excretion for 2 days varied 5 to 40% of the administered dose and was less in the patients with more metastatic lesions.

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