Superior Pituitary Border Analysis in Immunotherapy-Induced Hypophysitis

Darko Pucar, Anne Marie Boustani, Richard A. Bronen, Lawrence Saperstein

Research output: Contribution to journalArticle

Abstract

Immunotherapy-induced hypophysitis presents with headache, fatigue, and visual disturbances. The diagnosis is supported by imaging findings of pituitary swelling, enhancement, and hypermetabolism and established by low levels of pituitary hormones. A 64-year-old man with metastatic melanoma on nivolumab presented with a severe headache, initially attributed to sinus disease. Contrast CT was interpreted as minor sinus disease and no pituitary abnormality. Hypophysitis was eventually diagnosed and successfully treated based on PET and laboratory findings. Our retrospective analysis demonstrated abnormal convex superior pituitary border visible on contrast and noncontrast CT and PET. This feature may aid diagnosis in the challenging cases.

Original languageEnglish (US)
Pages (from-to)284-286
Number of pages3
JournalClinical Nuclear Medicine
Volume43
Issue number4
DOIs
StatePublished - Apr 1 2018

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Immunotherapy
Headache
Asthenopia
Pituitary Diseases
Pituitary Hormones
Melanoma
Hypophysitis
Positron Emission Tomography Computed Tomography
nivolumab

Keywords

  • FDG PET/CT
  • border analysis
  • immunotherapy
  • pituitary

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Superior Pituitary Border Analysis in Immunotherapy-Induced Hypophysitis. / Pucar, Darko; Boustani, Anne Marie; Bronen, Richard A.; Saperstein, Lawrence.

In: Clinical Nuclear Medicine, Vol. 43, No. 4, 01.04.2018, p. 284-286.

Research output: Contribution to journalArticle

Pucar, Darko ; Boustani, Anne Marie ; Bronen, Richard A. ; Saperstein, Lawrence. / Superior Pituitary Border Analysis in Immunotherapy-Induced Hypophysitis. In: Clinical Nuclear Medicine. 2018 ; Vol. 43, No. 4. pp. 284-286.
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