Superiority of frailty over age in predicting outcomes among geriatric trauma patients

A prospective analysis

Bellal Joseph, Viraj Pandit, Bardiya Zangbar, Narong Kulvatunyou, Ammar Hashmi, Donald J. Green, Terence OKeeffe, Andrew Tang, Gary Vercruysse, Mindy J. Fain, Randall S. Friese, Peter Rhee

Research output: Contribution to journalArticle

Abstract

IMPORTANCE The Frailty Index (FI) is a known predictor of adverse outcomes in geriatric patients. The usefulness of the FI as an outcome measure in geriatric trauma patients is unknown. OBJECTIVE To assess the usefulness of the FI as an effective assessment tool in predicting adverse outcomes in geriatric trauma patients. DESIGN, SETTING, AND PARTICIPANTS A 2-year (June 2011 to February 2013) prospective cohort study at a level I trauma center at the University of Arizona.We prospectively measured frailty in all geriatric trauma patients. Geriatric patients were defined as those 65 years or older. The FI was calculated using 50 preadmission frailty variables. Frailty in patients was defined by an FI of 0.25 or higher. MAIN OUTCOMES AND MEASURES The primary outcome measurewas in-hospital complications. The secondary outcome measure was adverse discharge disposition. In-hospital complications were defined as cardiac, pulmonary, infectious, hematologic, renal, and reoperation. Adverse discharge disposition was defined as discharge to a skilled nursing facility or in-hospital mortality. Multivariate logistic regression was used to assess the relationship between the FI and outcomes. RESULTS In total, 250 patients were enrolled, with a mean (SD) age of 77.9 (8.1) years, median Injury Severity Score of 15 (range, 9-18), median Glasgow Coma Scale score of 15 (range, 12-15), and mean (SD) FI of 0.21 (0.10). Forty-four percent (n = 110) of patients had frailty. Patients with frailty were more likely to have in-hospital complications (odds ratio, 2.5; 95% CI, 1.5-6.0; P = .001) and adverse discharge disposition (odds ratio, 1.6; 95%CI, 1.1-2.4; P = .001). The mortality rate was 2.0%(n = 5), and all patients who died had frailty. CONCLUSIONS AND RELEVANCE The FI is an independent predictor of in-hospital complications and adverse discharge disposition in geriatric trauma patients. This index should be used as a clinical tool for risk stratification in this patient group.

Original languageEnglish (US)
Pages (from-to)766-772
Number of pages7
JournalJAMA Surgery
Volume149
Issue number8
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Geriatrics
Wounds and Injuries
Odds Ratio
Outcome Assessment (Health Care)
Skilled Nursing Facilities
Glasgow Coma Scale
Injury Severity Score
Trauma Centers
Hospital Mortality
Reoperation
varespladib methyl
Cohort Studies
Logistic Models
Prospective Studies
Kidney
Lung
Mortality

ASJC Scopus subject areas

  • Surgery

Cite this

Joseph, B., Pandit, V., Zangbar, B., Kulvatunyou, N., Hashmi, A., Green, D. J., ... Rhee, P. (2014). Superiority of frailty over age in predicting outcomes among geriatric trauma patients: A prospective analysis. JAMA Surgery, 149(8), 766-772. https://doi.org/10.1001/jamasurg.2014.296

Superiority of frailty over age in predicting outcomes among geriatric trauma patients : A prospective analysis. / Joseph, Bellal; Pandit, Viraj; Zangbar, Bardiya; Kulvatunyou, Narong; Hashmi, Ammar; Green, Donald J.; OKeeffe, Terence; Tang, Andrew; Vercruysse, Gary; Fain, Mindy J.; Friese, Randall S.; Rhee, Peter.

In: JAMA Surgery, Vol. 149, No. 8, 01.01.2014, p. 766-772.

Research output: Contribution to journalArticle

Joseph, B, Pandit, V, Zangbar, B, Kulvatunyou, N, Hashmi, A, Green, DJ, OKeeffe, T, Tang, A, Vercruysse, G, Fain, MJ, Friese, RS & Rhee, P 2014, 'Superiority of frailty over age in predicting outcomes among geriatric trauma patients: A prospective analysis', JAMA Surgery, vol. 149, no. 8, pp. 766-772. https://doi.org/10.1001/jamasurg.2014.296
Joseph, Bellal ; Pandit, Viraj ; Zangbar, Bardiya ; Kulvatunyou, Narong ; Hashmi, Ammar ; Green, Donald J. ; OKeeffe, Terence ; Tang, Andrew ; Vercruysse, Gary ; Fain, Mindy J. ; Friese, Randall S. ; Rhee, Peter. / Superiority of frailty over age in predicting outcomes among geriatric trauma patients : A prospective analysis. In: JAMA Surgery. 2014 ; Vol. 149, No. 8. pp. 766-772.
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AU - Zangbar, Bardiya

AU - Kulvatunyou, Narong

AU - Hashmi, Ammar

AU - Green, Donald J.

AU - OKeeffe, Terence

AU - Tang, Andrew

AU - Vercruysse, Gary

AU - Fain, Mindy J.

AU - Friese, Randall S.

AU - Rhee, Peter

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N2 - IMPORTANCE The Frailty Index (FI) is a known predictor of adverse outcomes in geriatric patients. The usefulness of the FI as an outcome measure in geriatric trauma patients is unknown. OBJECTIVE To assess the usefulness of the FI as an effective assessment tool in predicting adverse outcomes in geriatric trauma patients. DESIGN, SETTING, AND PARTICIPANTS A 2-year (June 2011 to February 2013) prospective cohort study at a level I trauma center at the University of Arizona.We prospectively measured frailty in all geriatric trauma patients. Geriatric patients were defined as those 65 years or older. The FI was calculated using 50 preadmission frailty variables. Frailty in patients was defined by an FI of 0.25 or higher. MAIN OUTCOMES AND MEASURES The primary outcome measurewas in-hospital complications. The secondary outcome measure was adverse discharge disposition. In-hospital complications were defined as cardiac, pulmonary, infectious, hematologic, renal, and reoperation. Adverse discharge disposition was defined as discharge to a skilled nursing facility or in-hospital mortality. Multivariate logistic regression was used to assess the relationship between the FI and outcomes. RESULTS In total, 250 patients were enrolled, with a mean (SD) age of 77.9 (8.1) years, median Injury Severity Score of 15 (range, 9-18), median Glasgow Coma Scale score of 15 (range, 12-15), and mean (SD) FI of 0.21 (0.10). Forty-four percent (n = 110) of patients had frailty. Patients with frailty were more likely to have in-hospital complications (odds ratio, 2.5; 95% CI, 1.5-6.0; P = .001) and adverse discharge disposition (odds ratio, 1.6; 95%CI, 1.1-2.4; P = .001). The mortality rate was 2.0%(n = 5), and all patients who died had frailty. CONCLUSIONS AND RELEVANCE The FI is an independent predictor of in-hospital complications and adverse discharge disposition in geriatric trauma patients. This index should be used as a clinical tool for risk stratification in this patient group.

AB - IMPORTANCE The Frailty Index (FI) is a known predictor of adverse outcomes in geriatric patients. The usefulness of the FI as an outcome measure in geriatric trauma patients is unknown. OBJECTIVE To assess the usefulness of the FI as an effective assessment tool in predicting adverse outcomes in geriatric trauma patients. DESIGN, SETTING, AND PARTICIPANTS A 2-year (June 2011 to February 2013) prospective cohort study at a level I trauma center at the University of Arizona.We prospectively measured frailty in all geriatric trauma patients. Geriatric patients were defined as those 65 years or older. The FI was calculated using 50 preadmission frailty variables. Frailty in patients was defined by an FI of 0.25 or higher. MAIN OUTCOMES AND MEASURES The primary outcome measurewas in-hospital complications. The secondary outcome measure was adverse discharge disposition. In-hospital complications were defined as cardiac, pulmonary, infectious, hematologic, renal, and reoperation. Adverse discharge disposition was defined as discharge to a skilled nursing facility or in-hospital mortality. Multivariate logistic regression was used to assess the relationship between the FI and outcomes. RESULTS In total, 250 patients were enrolled, with a mean (SD) age of 77.9 (8.1) years, median Injury Severity Score of 15 (range, 9-18), median Glasgow Coma Scale score of 15 (range, 12-15), and mean (SD) FI of 0.21 (0.10). Forty-four percent (n = 110) of patients had frailty. Patients with frailty were more likely to have in-hospital complications (odds ratio, 2.5; 95% CI, 1.5-6.0; P = .001) and adverse discharge disposition (odds ratio, 1.6; 95%CI, 1.1-2.4; P = .001). The mortality rate was 2.0%(n = 5), and all patients who died had frailty. CONCLUSIONS AND RELEVANCE The FI is an independent predictor of in-hospital complications and adverse discharge disposition in geriatric trauma patients. This index should be used as a clinical tool for risk stratification in this patient group.

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