TY - JOUR
T1 - Supply and demand for endocannabinoids
AU - Alger, Bradley E.
AU - Kim, Jimok
N1 - Funding Information:
Research in the laboratories of the authors was supported by National Institutes of Health grants R01 DA014625 and R01 MH077277 to B.E.A. and R01 AG036794 to J.K.
PY - 2011/6
Y1 - 2011/6
N2 - The endocannabinoid system consists of G-protein-coupled cannabinoid receptors that can be activated by cannabis-derived drugs and small lipids termed endocannabinoids (eCBs) plus associated biochemical machinery (precursors, synthetic and degradative enzymes, transporters). The eCB system in the brain primarily influences neuronal synaptic communication, and affects biological functions - including eating, anxiety, learning and memory, growth and development - via an array of actions throughout the nervous system. Although many aspects of synaptic regulation by eCBs are becoming clear, details of the subcellular organization and regulation of the eCB system are less well understood. This review focuses on recent investigations that illuminate fundamental issues of eCB storage, release, and functional roles.
AB - The endocannabinoid system consists of G-protein-coupled cannabinoid receptors that can be activated by cannabis-derived drugs and small lipids termed endocannabinoids (eCBs) plus associated biochemical machinery (precursors, synthetic and degradative enzymes, transporters). The eCB system in the brain primarily influences neuronal synaptic communication, and affects biological functions - including eating, anxiety, learning and memory, growth and development - via an array of actions throughout the nervous system. Although many aspects of synaptic regulation by eCBs are becoming clear, details of the subcellular organization and regulation of the eCB system are less well understood. This review focuses on recent investigations that illuminate fundamental issues of eCB storage, release, and functional roles.
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U2 - 10.1016/j.tins.2011.03.003
DO - 10.1016/j.tins.2011.03.003
M3 - Review article
C2 - 21507493
AN - SCOPUS:79957551226
SN - 0166-2236
VL - 34
SP - 304
EP - 315
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 6
ER -