Suppressed bone remodeling in black bears conserves energy and bone mass during hibernation

Meghan McGee-Lawrence, Patricia Buckendahl, Caren Carpenter, Kim Henriksen, Michael Vaughan, Seth Donahue

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Decreased physical activity in mammals increases bone turnover and uncouples bone formation from bone resorption, leading to hypercalcemia, hypercalcuria, bone loss and increased fracture risk. Black bears, however, are physically inactive for up to 6 months annually during hibernation without losing cortical or trabecular bone mass. Bears have been shown to preserve trabecular bone volume and architectural parameters and cortical bone strength, porosity and geometrical properties during hibernation. The mechanisms that prevent disuse osteoporosis in bears are unclear as previous studies using histological and serum markers of bone remodeling show conflicting results. However, previous studies used serum markers of bone remodeling that are known to accumulate with decreased renal function, which bears have during hibernation. Therefore, we measured serum bone remodeling markers (BSALP and TRACP) that do not accumulate with decreased renal function, in addition to the concentrations of serum calcium and hormones involved in regulating bone remodeling in hibernating and active bears. Bone resorption and formation markers were decreased during hibernation compared with when bears were physically active, and these findings were supported by histomorphometric analyses of bone biopsies. The serum concentration of cocaine and amphetamine regulated transcript (CART), a hormone known to reduce bone resorption, was 15-fold higher during hibernation. Serum calcium concentration was unchanged between hibernation and non-hibernation seasons. Suppressed and balanced bone resorption and formation in hibernating bears contributes to energy conservation, eucalcemia and the preservation of bone mass and strength, allowing bears to survive prolonged periods of extreme environmental conditions, nutritional deprivation and anuria.

Original languageEnglish (US)
Pages (from-to)2067-2074
Number of pages8
JournalJournal of Experimental Biology
Volume218
Issue number13
DOIs
StatePublished - Jul 1 2015

Fingerprint

Ursidae
Hibernation
hibernation
Bone Remodeling
bone
bones
Bone Resorption
Bone and Bones
energy
Osteogenesis
bone resorption
Serum
serum
bone formation
resorption
Biomarkers
Hormones
Calcium
Anuria
Kidney

Keywords

  • CART
  • Calcium metabolism
  • Disuse
  • Skeletal adaptation
  • Ursus americanus

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Physiology
  • Aquatic Science
  • Animal Science and Zoology
  • Molecular Biology
  • Insect Science

Cite this

Suppressed bone remodeling in black bears conserves energy and bone mass during hibernation. / McGee-Lawrence, Meghan; Buckendahl, Patricia; Carpenter, Caren; Henriksen, Kim; Vaughan, Michael; Donahue, Seth.

In: Journal of Experimental Biology, Vol. 218, No. 13, 01.07.2015, p. 2067-2074.

Research output: Contribution to journalArticle

McGee-Lawrence, Meghan ; Buckendahl, Patricia ; Carpenter, Caren ; Henriksen, Kim ; Vaughan, Michael ; Donahue, Seth. / Suppressed bone remodeling in black bears conserves energy and bone mass during hibernation. In: Journal of Experimental Biology. 2015 ; Vol. 218, No. 13. pp. 2067-2074.
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