Surface changes in rat gastric mucosa induced by sodium fluoride: a scanning electron microscopic study

R. P. Easmann, D. E. Steflik, D. H. Pashley, R. V. McKinnny, G. M. Whitford

Research output: Contribution to journalArticle

18 Scopus citations


This paper describes the ultrastructural, topographical changes seen in rat gastric mucosa following application of 0.1 N HC1 or 1,10 or 50 niM NaF in 0.1 N HC1 to the stomach. No morphological differences were noticed between the 0.1 N HC1 (control) and 1 mM NaF in 0.1 N HCI specimens. Ten milliomolar NaF in 0.1 N HC1 produced some desquamation of surface mucous epithelial cells while 50 mM NaF produced extensive damage to cells surrounding the gastric gland openings (foveolae) as well as inlerfoveolar cell loss.

Original languageEnglish (US)
Pages (from-to)255-264
Number of pages10
JournalJournal of Oral Pathology & Medicine
Issue number3
StatePublished - Jun 1984


ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

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