Abstract
Purpose: The influence of surface modifications on osseointegration in newly formed bone is not well established. The purpose of this study was to compare osseointegration at acid-etched versus turned implants in newly formed and native bone. Methods: Supra-alveolar peri-implant defects were created in 8 hound/Labrador mongrel dogs. Titanium implants 10 mm long (2 turned and 1 dual acid-etched) were placed 5 mm into the surgically reduced alveolar crest, creating 5-mm supra-alveolar peri-implant defects. Recombinant human bone morphogenetic protein-2 (rhBMP-2; 0.4 mg) in a collagen carrier was used to induce new bone formation. A macroporous, expanded polytetrafluoroethylene device was used to delineate new bone formation. The animals were euthanized at 8 weeks for histometric analysis of the experimental sites. Results: There were no significant differences in rhBMP-2-induced bone density (mean ± SD) at acid-etched versus turned implants (20.6% ± 5.3% vs 23.8% ± 4.7%; P = .232). However, there was a significant difference in bone-implant contact in favor of the acid-etched implants (12.3% ± 6.8% vs 7.9% ± 3.1%; P = .05). Native bone density averaged 63.9% ± 7.5% and 64.5% ± 9.0% for acid-etched and turned implants, respectively (P = .641). Nevertheless, bone-implant contact was significantly enhanced at acid-etched versus turned implants (59.7% ± 11.3% vs 40.7% ± 21.2%; P = .005). Conclusions: Surface dual acid-etching of titanium implants has a positive effect on osseointegration in newly formed and native bone. Significant differences in bone density do not appear to influence this effect.
Original language | English (US) |
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Pages (from-to) | 472-477 |
Number of pages | 6 |
Journal | International Journal of Oral and Maxillofacial Implants |
Volume | 22 |
Issue number | 3 |
State | Published - May 2007 |
Keywords
- Bone
- Osseointegration
- Tissue engineering
- Titanium implants
- e-PTFE
- rhBMP-2
ASJC Scopus subject areas
- Oral Surgery