Surface-etching enhances titanium implant osseointegration in newly formed (rhBMP-2-Induced) and native bone

Mohammed Qahash, W. Ross Hardwick, Michael D. Rohrer, John M. Wozney, Ulf M E Wikesjö

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: The influence of surface modifications on osseointegration in newly formed bone is not well established. The purpose of this study was to compare osseointegration at acid-etched versus turned implants in newly formed and native bone. Methods: Supra-alveolar peri-implant defects were created in 8 hound/Labrador mongrel dogs. Titanium implants 10 mm long (2 turned and 1 dual acid-etched) were placed 5 mm into the surgically reduced alveolar crest, creating 5-mm supra-alveolar peri-implant defects. Recombinant human bone morphogenetic protein-2 (rhBMP-2; 0.4 mg) in a collagen carrier was used to induce new bone formation. A macroporous, expanded polytetrafluoroethylene device was used to delineate new bone formation. The animals were euthanized at 8 weeks for histometric analysis of the experimental sites. Results: There were no significant differences in rhBMP-2-induced bone density (mean ± SD) at acid-etched versus turned implants (20.6% ± 5.3% vs 23.8% ± 4.7%; P = .232). However, there was a significant difference in bone-implant contact in favor of the acid-etched implants (12.3% ± 6.8% vs 7.9% ± 3.1%; P = .05). Native bone density averaged 63.9% ± 7.5% and 64.5% ± 9.0% for acid-etched and turned implants, respectively (P = .641). Nevertheless, bone-implant contact was significantly enhanced at acid-etched versus turned implants (59.7% ± 11.3% vs 40.7% ± 21.2%; P = .005). Conclusions: Surface dual acid-etching of titanium implants has a positive effect on osseointegration in newly formed and native bone. Significant differences in bone density do not appear to influence this effect.

Original languageEnglish (US)
Pages (from-to)472-477
Number of pages6
JournalInternational Journal of Oral and Maxillofacial Implants
Volume22
Issue number3
StatePublished - May 1 2007

Fingerprint

Osseointegration
Titanium
Bone and Bones
Acids
Bone Density
Osteogenesis
Newfoundland and Labrador
Polytetrafluoroethylene
Collagen
Dogs
Equipment and Supplies

Keywords

  • Bone
  • Osseointegration
  • Tissue engineering
  • Titanium implants
  • e-PTFE
  • rhBMP-2

ASJC Scopus subject areas

  • Oral Surgery

Cite this

Qahash, M., Ross Hardwick, W., Rohrer, M. D., Wozney, J. M., & Wikesjö, U. M. E. (2007). Surface-etching enhances titanium implant osseointegration in newly formed (rhBMP-2-Induced) and native bone. International Journal of Oral and Maxillofacial Implants, 22(3), 472-477.

Surface-etching enhances titanium implant osseointegration in newly formed (rhBMP-2-Induced) and native bone. / Qahash, Mohammed; Ross Hardwick, W.; Rohrer, Michael D.; Wozney, John M.; Wikesjö, Ulf M E.

In: International Journal of Oral and Maxillofacial Implants, Vol. 22, No. 3, 01.05.2007, p. 472-477.

Research output: Contribution to journalArticle

Qahash, Mohammed ; Ross Hardwick, W. ; Rohrer, Michael D. ; Wozney, John M. ; Wikesjö, Ulf M E. / Surface-etching enhances titanium implant osseointegration in newly formed (rhBMP-2-Induced) and native bone. In: International Journal of Oral and Maxillofacial Implants. 2007 ; Vol. 22, No. 3. pp. 472-477.
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abstract = "Purpose: The influence of surface modifications on osseointegration in newly formed bone is not well established. The purpose of this study was to compare osseointegration at acid-etched versus turned implants in newly formed and native bone. Methods: Supra-alveolar peri-implant defects were created in 8 hound/Labrador mongrel dogs. Titanium implants 10 mm long (2 turned and 1 dual acid-etched) were placed 5 mm into the surgically reduced alveolar crest, creating 5-mm supra-alveolar peri-implant defects. Recombinant human bone morphogenetic protein-2 (rhBMP-2; 0.4 mg) in a collagen carrier was used to induce new bone formation. A macroporous, expanded polytetrafluoroethylene device was used to delineate new bone formation. The animals were euthanized at 8 weeks for histometric analysis of the experimental sites. Results: There were no significant differences in rhBMP-2-induced bone density (mean ± SD) at acid-etched versus turned implants (20.6{\%} ± 5.3{\%} vs 23.8{\%} ± 4.7{\%}; P = .232). However, there was a significant difference in bone-implant contact in favor of the acid-etched implants (12.3{\%} ± 6.8{\%} vs 7.9{\%} ± 3.1{\%}; P = .05). Native bone density averaged 63.9{\%} ± 7.5{\%} and 64.5{\%} ± 9.0{\%} for acid-etched and turned implants, respectively (P = .641). Nevertheless, bone-implant contact was significantly enhanced at acid-etched versus turned implants (59.7{\%} ± 11.3{\%} vs 40.7{\%} ± 21.2{\%}; P = .005). Conclusions: Surface dual acid-etching of titanium implants has a positive effect on osseointegration in newly formed and native bone. Significant differences in bone density do not appear to influence this effect.",
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AU - Wikesjö, Ulf M E

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AB - Purpose: The influence of surface modifications on osseointegration in newly formed bone is not well established. The purpose of this study was to compare osseointegration at acid-etched versus turned implants in newly formed and native bone. Methods: Supra-alveolar peri-implant defects were created in 8 hound/Labrador mongrel dogs. Titanium implants 10 mm long (2 turned and 1 dual acid-etched) were placed 5 mm into the surgically reduced alveolar crest, creating 5-mm supra-alveolar peri-implant defects. Recombinant human bone morphogenetic protein-2 (rhBMP-2; 0.4 mg) in a collagen carrier was used to induce new bone formation. A macroporous, expanded polytetrafluoroethylene device was used to delineate new bone formation. The animals were euthanized at 8 weeks for histometric analysis of the experimental sites. Results: There were no significant differences in rhBMP-2-induced bone density (mean ± SD) at acid-etched versus turned implants (20.6% ± 5.3% vs 23.8% ± 4.7%; P = .232). However, there was a significant difference in bone-implant contact in favor of the acid-etched implants (12.3% ± 6.8% vs 7.9% ± 3.1%; P = .05). Native bone density averaged 63.9% ± 7.5% and 64.5% ± 9.0% for acid-etched and turned implants, respectively (P = .641). Nevertheless, bone-implant contact was significantly enhanced at acid-etched versus turned implants (59.7% ± 11.3% vs 40.7% ± 21.2%; P = .005). Conclusions: Surface dual acid-etching of titanium implants has a positive effect on osseointegration in newly formed and native bone. Significant differences in bone density do not appear to influence this effect.

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