Surfactant apoprotein in nonmalignant pulmonary disorders

Gurmukh Singh, S. L. Katyal

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Formalin-fixed, paraffin-embedded lungs exhibiting a variety of nonmalignant disorders were studied by immunoperoxidase staining using antibodies specific for surfactant apoprotein, IgG, IgM, IgA, albumin, fibrinogen, and lysozyme. Normal Type II pneumocytes showed staining for surfactant apoprotein in the perinuclear region only. The extent and intensity of staining for apoprotein was markedly increased in reactive Type II pneumocytes. This increase appeared to be a nonspecific reaction to lung injury. The intraalveolar material in pulmonary alveolar proteinosis stained intensely for surfactant apoprotein, indicating that the accumulated proteinaceous material contained pulmonary surfactant. Type II pneumocytes in pulmonary alveolar proteinosis exhibited hyperplasia as well as hypertrophy. The few macrophages in lung affected by pulmonary alveolar proteinosis stained intensely for lysozyme. The excessive intraalveolar accumulation of proteinaceous material in pulmonary alveolar proteinosis may be the result of both an overproduction as well as a deficient removal of pulmonary surfactant.

Original languageEnglish (US)
Pages (from-to)51-61
Number of pages11
JournalAmerican Journal of Pathology
Volume101
Issue number1
StatePublished - Jan 1 1980

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Pulmonary Alveolar Proteinosis
Apoproteins
Alveolar Epithelial Cells
Surface-Active Agents
Pulmonary Surfactants
Lung
Muramidase
Staining and Labeling
Lung Injury
Paraffin
Fibrinogen
Immunoglobulin A
Hypertrophy
Formaldehyde
Hyperplasia
Immunoglobulin M
Albumins
Immunoglobulin G
Macrophages
Antibodies

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Surfactant apoprotein in nonmalignant pulmonary disorders. / Singh, Gurmukh; Katyal, S. L.

In: American Journal of Pathology, Vol. 101, No. 1, 01.01.1980, p. 51-61.

Research output: Contribution to journalArticle

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