Surgery versus radiation therapy for stage IB2 cervical carcinoma: A population-based analysis

Bunja Rungruang, Madeleine Courtney-Brooks, Sushil Beriwal, Kristin K. Zorn, Scott D. Richard, Alexander B. Olawaiye, Thomas C. Krivak, Paniti Sukumvanich

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Objective: The objective of the study was to examine outcomes in stage IB2 cervical cancer patients undergoing primary surgery versus radiation. Methods: Stage IB2 cervical cancer patients were identified from the Surveillance, Epidemiology and End Results Public-Use Database from 2000 to 2006. Patients were divided into those receiving radiation (radiation first) or surgery (surgery first) as initial treatment. Overall survival was calculated by Kaplan-Meier method and compared using log-rank test. Results: In total, 770 patients were identified with stage IB2 cervical cancer; 369 received radiation, and 401 received surgery initially. The radiation-first group had larger mean tumor size than the surgery-first group (6.0 vs 5.5 cm, respectively; P < 0.0001). The overall survival was longer in the surgery-first group compared with the radiation-first group (72.0 vs 61.4 months, respectively; P < 0.0001). Conclusions: Patients undergoing surgery as initial treatment for stage IB2 cervical cancer appear to have improved outcomes in the current era of chemoradiation; however, given the lack of chemotherapy information, a randomized trial will be necessary to see if these results remain valid.

Original languageEnglish (US)
Pages (from-to)484-489
Number of pages6
JournalInternational Journal of Gynecological Cancer
Volume22
Issue number3
DOIs
StatePublished - Mar 1 2012
Externally publishedYes

Keywords

  • Cervical cancer
  • Chemoradiation
  • Radiation
  • Radical hysterectomy

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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    Rungruang, B., Courtney-Brooks, M., Beriwal, S., Zorn, K. K., Richard, S. D., Olawaiye, A. B., Krivak, T. C., & Sukumvanich, P. (2012). Surgery versus radiation therapy for stage IB2 cervical carcinoma: A population-based analysis. International Journal of Gynecological Cancer, 22(3), 484-489. https://doi.org/10.1097/IGC.0b013e31823f890f