Surgical Pathology of the Mitral Valve: A Study of 712 Cases Spanning 21 Years

LYLE J. OLSON, Ramiah Subramanian, DOUGLAS M. ACKERMANN, THOMAS A. ORSZULAK, WILLIAM D. EDWARDS

Research output: Contribution to journalArticle

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Abstract

The gross surgical pathologic features of the mitral valve were reviewed in 712 patients who had undergone mitral valve replacement at our institution during 1965, 1970, 1975, 1980, and 1985. Among the 452 cases of mitral stenosis, either with or without mitral insufficiency, 99% were attributable to postinflammatory disease and 1% were related to congenital mitral stenosis. Among the 260 cases of pure mitral regurgitation, the two most common causes were a floppy valve (38%) and postinflammatory disease (31%). Moreover, a floppy valve was observed in 73% of the 59 examples of chordal rupture and in 38% of the 16 cases of infective endocarditis. Women accounted for 73% of the 452 cases of mitral stenosis and for 72% of the 530 cases of postinflammatory disease. In contrast, men accounted for 58% of the 260 cases of pure mitral regurgitation, including 76% of the floppy valves and 69% of the infected valves. During the 21 years spanned by the study, the relative frequency of postinflammatory mitral insufficiency progressively decreased, whereas that of floppy mitral valves increased. It is unclear whether aging, heredity, environmental factors, changes in the frequency of acute rheumatic fever, or changes in patient referral practices may account for this observation.

Original languageEnglish (US)
Pages (from-to)22-34
Number of pages13
JournalMayo Clinic Proceedings
Volume62
Issue number1
DOIs
StatePublished - Jan 1 1987

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Surgical Pathology
Mitral Valve Insufficiency
Mitral Valve
Mitral Valve Stenosis
Mitral Valve Prolapse
Heredity
Rheumatic Fever
Endocarditis
Rupture
Referral and Consultation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

OLSON, LYLE. J., Subramanian, R., ACKERMANN, DOUGLAS. M., ORSZULAK, THOMAS. A., & EDWARDS, WILLIAM. D. (1987). Surgical Pathology of the Mitral Valve: A Study of 712 Cases Spanning 21 Years. Mayo Clinic Proceedings, 62(1), 22-34. https://doi.org/10.1016/S0025-6196(12)61522-5

Surgical Pathology of the Mitral Valve : A Study of 712 Cases Spanning 21 Years. / OLSON, LYLE J.; Subramanian, Ramiah; ACKERMANN, DOUGLAS M.; ORSZULAK, THOMAS A.; EDWARDS, WILLIAM D.

In: Mayo Clinic Proceedings, Vol. 62, No. 1, 01.01.1987, p. 22-34.

Research output: Contribution to journalArticle

OLSON, LYLEJ, Subramanian, R, ACKERMANN, DOUGLASM, ORSZULAK, THOMASA & EDWARDS, WILLIAMD 1987, 'Surgical Pathology of the Mitral Valve: A Study of 712 Cases Spanning 21 Years', Mayo Clinic Proceedings, vol. 62, no. 1, pp. 22-34. https://doi.org/10.1016/S0025-6196(12)61522-5
OLSON LYLEJ, Subramanian R, ACKERMANN DOUGLASM, ORSZULAK THOMASA, EDWARDS WILLIAMD. Surgical Pathology of the Mitral Valve: A Study of 712 Cases Spanning 21 Years. Mayo Clinic Proceedings. 1987 Jan 1;62(1):22-34. https://doi.org/10.1016/S0025-6196(12)61522-5
OLSON, LYLE J. ; Subramanian, Ramiah ; ACKERMANN, DOUGLAS M. ; ORSZULAK, THOMAS A. ; EDWARDS, WILLIAM D. / Surgical Pathology of the Mitral Valve : A Study of 712 Cases Spanning 21 Years. In: Mayo Clinic Proceedings. 1987 ; Vol. 62, No. 1. pp. 22-34.
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