Survival of nerve and Schwann cells in allografts after Cyclosporin A treatment

Andrew A. Zalewski, Adarsh K Gulati

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Because nerve and Schwann cells in allografts are rejected by normal rats, we investigated whether or not these neurological cells would survive if rats were treated with the new immunosuppressive drug, Cyclosporin A. Untreated rats rejected nerve and Schwann cells in allografts of ganglia or nerve. On the other hand, nerve and Schwann cells survived in allografts in Cyclosporin A-treated rats even after drug therapy was terminated. These results indicate that Cyclosporin A may be of value if allogenic nerve or Schwann cells are needed to aid in the repair of injured nerve tissue.

Original languageEnglish (US)
Pages (from-to)219-225
Number of pages7
JournalExperimental Neurology
Volume70
Issue number2
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

Fingerprint

Schwann Cells
Cyclosporine
Allografts
Neurons
Nerve Tissue
Therapeutics
Immunosuppressive Agents
Ganglia
Drug Therapy
Pharmaceutical Preparations

Keywords

  • BN
  • Brown Norway
  • CsA
  • Cyclosporin A
  • EDL
  • LE
  • Lewis
  • PAS
  • TA
  • extensor digitorum longus
  • hematoxylin—periodic acid-Schiff-hematoxylin
  • tibialis anterior

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

Cite this

Survival of nerve and Schwann cells in allografts after Cyclosporin A treatment. / Zalewski, Andrew A.; Gulati, Adarsh K.

In: Experimental Neurology, Vol. 70, No. 2, 01.01.1980, p. 219-225.

Research output: Contribution to journalArticle

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