Abstract
Repeated restraint stress 3 h/day for 3 days in rats causes a temporary hypophagia but a sustained weight loss. We investigated whether poststress changes in peripheral tissue metabolism contributed to these responses. One day after the last restraint, insulin sensitivity, measured by oral glucose tolerance test, was improved in restrained rats. Restraint and pair-fed rats weighed less than controls, but body fat content was the same in all groups. Muscle glucose uptake, measured in vitro, was not changed by treatment, whereas in vitro adipocyte glucose uptake was substantially inhibited only in restrained rats. Adipocytes from restrained rats had elevated rates of fatty acid oxidation but not fatty acid esterification, indicating a shift in energy supply from glucose to fatty acids. Five days after the last restraint, the reduced weight of restrained and pair-fed rats resulted from loss of both lean and fat tissue. These results demonstrate that restraint caused sustained, tissue-specific changes in metabolism that may contribute to changes in body composition and body weight of the rats.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Physiology - Regulatory Integrative and Comparative Physiology |
| Volume | 277 |
| Issue number | 3 46-3 |
| State | Published - Sep 1 1999 |
| Externally published | Yes |
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Keywords
- Body composition
- Fatty acid oxidation
- Glucose tolerance
- Glucose transport
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
Sustained effects of repeated restraint stress on muscle and adipocyte metabolism in high-fat-fed rats. / Zhou, Jun; Yan, Xiaolang; Ryan, Donna H.; Harris, Ruth Babette.
In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 277, No. 3 46-3, 01.09.1999.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sustained effects of repeated restraint stress on muscle and adipocyte metabolism in high-fat-fed rats
AU - Zhou, Jun
AU - Yan, Xiaolang
AU - Ryan, Donna H.
AU - Harris, Ruth Babette
PY - 1999/9/1
Y1 - 1999/9/1
N2 - Repeated restraint stress 3 h/day for 3 days in rats causes a temporary hypophagia but a sustained weight loss. We investigated whether poststress changes in peripheral tissue metabolism contributed to these responses. One day after the last restraint, insulin sensitivity, measured by oral glucose tolerance test, was improved in restrained rats. Restraint and pair-fed rats weighed less than controls, but body fat content was the same in all groups. Muscle glucose uptake, measured in vitro, was not changed by treatment, whereas in vitro adipocyte glucose uptake was substantially inhibited only in restrained rats. Adipocytes from restrained rats had elevated rates of fatty acid oxidation but not fatty acid esterification, indicating a shift in energy supply from glucose to fatty acids. Five days after the last restraint, the reduced weight of restrained and pair-fed rats resulted from loss of both lean and fat tissue. These results demonstrate that restraint caused sustained, tissue-specific changes in metabolism that may contribute to changes in body composition and body weight of the rats.
AB - Repeated restraint stress 3 h/day for 3 days in rats causes a temporary hypophagia but a sustained weight loss. We investigated whether poststress changes in peripheral tissue metabolism contributed to these responses. One day after the last restraint, insulin sensitivity, measured by oral glucose tolerance test, was improved in restrained rats. Restraint and pair-fed rats weighed less than controls, but body fat content was the same in all groups. Muscle glucose uptake, measured in vitro, was not changed by treatment, whereas in vitro adipocyte glucose uptake was substantially inhibited only in restrained rats. Adipocytes from restrained rats had elevated rates of fatty acid oxidation but not fatty acid esterification, indicating a shift in energy supply from glucose to fatty acids. Five days after the last restraint, the reduced weight of restrained and pair-fed rats resulted from loss of both lean and fat tissue. These results demonstrate that restraint caused sustained, tissue-specific changes in metabolism that may contribute to changes in body composition and body weight of the rats.
KW - Body composition
KW - Fatty acid oxidation
KW - Glucose tolerance
KW - Glucose transport
UR - http://www.scopus.com/inward/record.url?scp=0032834066&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032834066&partnerID=8YFLogxK
M3 - Article
VL - 277
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
SN - 0363-6135
IS - 3 46-3
ER -