Sweet-Tasting Ionic Conjugates of Local Anesthetics and Vasoconstrictors

John K. Neubert, Alexander A. Oliferenko, Polina V. Oliferenko, Sergey V. Emets, David A. Ostrov, Gary I. Altschuler, Joe Calkins, Jay Wickersham, Robert Hromas, Iryna O. Lebedyeva

Research output: Contribution to journalArticlepeer-review

Abstract

Local anesthetics are widely utilized in dentistry, cosmetology, and medicine. Local anesthesia is essential to providing a pain-free experience during dental and local surgeries as well as cosmetic procedures. However, the injection itself may produce discomfort and be a source of aversion. A novel approach toward the taste modulation of local anesthetics is proposed, in which the anesthetics of the "-caine" family serve as cations and are coupled with anionic sweeteners such as saccharinate and acesulfamate. Ionic conjugates of vasoconstrictor epinephrine such as epinephrine saccharinate and epinephrine acesulfamate have also been synthesized. Novel ionic conjugates were developed using anion exchange techniques. Reported compounds are sweet-tasting and are safe to use both topically and as injections.

Original languageEnglish (US)
JournalMolecules
Volume26
Issue number4
DOIs
StatePublished - Feb 12 2021

Keywords

  • anesthesia
  • dental
  • epinephrine
  • injectable anesthetic
  • lidocaine
  • local anesthesia
  • local anesthetic
  • sweetener
  • vasoconstrictor

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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