Synaptic tagging and long-term potentiation

Uwe Frey, Richard G.M. Morris

Research output: Contribution to journalArticle

1074 Citations (Scopus)

Abstract

Repeated stimulation of hippocampal neurons can induce an immediate and prolonged increase in synaptic strength that is called long-term potentiation (LTP-the primary cellullar model of memory in the mammalian brain. An early phase of LTP (lasting less than three hours) can be dissociated from late- phase LTP by using inhibitors of transcription and translation. Because protein synthesis occurs mainly in the cell body, whereas LTP is input- specific, the question arises of how the synapse specificity of late LTP is achieved without elaborate intracellular protein trafficking. We propose that LTp initiates the creation of a short-lasting protein-synthesis-independent 'synaptic tag' at the potentiated synapse which sequesters the relevant protein(s) to establish late LTP. In support of this idea, we now show that weak tetanic stimulation, which ordinarily leads only to early LTP, or repeated tetanization in the presence of protein-synthesis inhibitors, each results in protein-synthesis-dependent late LTP, provided repeated tetanization has already been applied at another input to the same population of neurons. The synaptic tag decays in less than three hours. These findings indicates that the persistence of LTP depends not only on local events during its induction, but also on the prior activity of the neuron.

Original languageEnglish (US)
Pages (from-to)533-536
Number of pages4
JournalNature
Volume385
Issue number6616
DOIs
StatePublished - Feb 6 1997

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Long-Term Potentiation
Neurons
Synapses
Proteins
Protein Synthesis Inhibitors
Protein Transport
Brain
Population

ASJC Scopus subject areas

  • General

Cite this

Frey, U., & Morris, R. G. M. (1997). Synaptic tagging and long-term potentiation. Nature, 385(6616), 533-536. https://doi.org/10.1038/385533a0

Synaptic tagging and long-term potentiation. / Frey, Uwe; Morris, Richard G.M.

In: Nature, Vol. 385, No. 6616, 06.02.1997, p. 533-536.

Research output: Contribution to journalArticle

Frey, U & Morris, RGM 1997, 'Synaptic tagging and long-term potentiation', Nature, vol. 385, no. 6616, pp. 533-536. https://doi.org/10.1038/385533a0
Frey U, Morris RGM. Synaptic tagging and long-term potentiation. Nature. 1997 Feb 6;385(6616):533-536. https://doi.org/10.1038/385533a0
Frey, Uwe ; Morris, Richard G.M. / Synaptic tagging and long-term potentiation. In: Nature. 1997 ; Vol. 385, No. 6616. pp. 533-536.
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