Synaptic tagging

Implications for late maintenance of hippocampal long- term potentiation

Julietta Uta Frey, Richard G.M. Morris

Research output: Contribution to journalArticle

421 Citations (Scopus)

Abstract

A novel property of hippocampal LTP, 'variable persistence', has recently been described that is, we argue, relevant to the role of LTP in information storage. Specifically, new results indicate that a particular pattern of synaptic activation can give rise, either to a relatively short- lasting LTP, or to a longer-lasting LTP as a function of the history of activation of the neuron. This has led to the idea that the induction of LTP is associated with the setting of a 'synaptic tag' at activated synapses, whose role is to sequester plasticity-related proteins that then serve to stabilize temporary synaptic changes and so extend their persistence. In this article, we outline the synaptic tag hypothesis, compare predictions it makes with those of other theories about the persistence of LTP, and speculate about the cellular identity of the tag. In addition, we outline the requirement for aminergic activation to induce late LTP and consider the functional implications of the synaptic tag hypothesis with respect to long- term memory.

Original languageEnglish (US)
Pages (from-to)181-188
Number of pages8
JournalTrends in Neurosciences
Volume21
Issue number5
DOIs
StatePublished - May 1 1998

Fingerprint

Long-Term Memory
Long-Term Potentiation
Information Storage and Retrieval
Synapses
History
Neurons
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Synaptic tagging : Implications for late maintenance of hippocampal long- term potentiation. / Frey, Julietta Uta; Morris, Richard G.M.

In: Trends in Neurosciences, Vol. 21, No. 5, 01.05.1998, p. 181-188.

Research output: Contribution to journalArticle

Frey, Julietta Uta ; Morris, Richard G.M. / Synaptic tagging : Implications for late maintenance of hippocampal long- term potentiation. In: Trends in Neurosciences. 1998 ; Vol. 21, No. 5. pp. 181-188.
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