Synergistic Effects of Multiple Factors Involved in COVID-19-dependent Muscle Loss

Nicholas Cantu, Sagar Vyavahare, Sandeep Kumar, Jie Chen, Ravindra Kolhe, Carlos M. Isales, Mark Hamrick, Sadanand Fulzele

Research output: Contribution to journalArticlepeer-review

Abstract

The COVID-19 pandemic caused by the novel SARS-CoV-2 coronavirus is an ongoing pandemic causing severe health crisis worldwide. Recovered COVID-19 patients go through several long-term side effects such as fatigue, headaches, dizziness, weight loss, and muscle loss among others. Our study sought to determine the molecular mechanisms behind muscle loss in COVID-19 patients. We hypothesized that multiple factors such as cytokine storm and therapeutic drugs (glucocorticoid and antiviral drugs) might be involved in muscle loss. Using the Gene Expression Omnibus database, we identified several studies that performed RNA sequencing on skeletal muscles with the treatment of cytokine, glucocorticoid, and antiviral drugs. Our study identified cytokines, such as IL-1b, and IL-6, associated with altered regulation of several genes involved in the myogenic processes, including Ttn, Cxxc5, Malat1, and Foxo1. We also observed that glucocorticoid altered the expression of Foxo1, Lcn2, Slc39a14, and Cdkn1a. Finally, we found out that the antiviral (RNA-dependent RNA polymerase inhibitor) drug regulates the expression of some of the muscle-related genes (Txnip, Ccnd1, Hdac9, and Fbxo32). Based on our findings, we hypothesize that the cytokine storm, glucocorticoids, and antiviral drugs might be synergistically involved in COVID-19-dependent muscle loss.

Original languageEnglish (US)
Pages (from-to)344-352
Number of pages9
JournalAging and Disease
Volume13
Issue number2
DOIs
StatePublished - Apr 1 2022

Keywords

  • COVID-19
  • Muscle loss
  • antiviral drugs
  • cytokine storm
  • glucocorticoid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cell Biology

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