Synergistic requirements for the induction of dopaminergic D1/D5-receptor-mediated LTP in hippocampal slices of rat CA1 in vitro

Sheeja Navakkode, Sreedharan Sajikumar, Julietta Uta Frey

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Dopaminergic D1/D5-receptor-mediated processes are important for certain forms of memory and its cellular model, i.e. hippocampal long-term potentiation (LTP) in CA1. D1/D5-receptor function is required for the induction of the protein synthesis-dependent maintenance of CA1-LTP (late-LTP) by activating the cAMP/PKA-pathway. In earlier studies we had reported a synergistic interaction of D1/D5-receptor function and N-methyl-d-aspartate (NMDA)-receptors (Frey, 2001, Long-lasting hippocampal plasticity: cellular model for memory consolidation? In: Richter, D. (Ed.), Cell Polarity and Subcellular RNA Localization. Springer-Verlag, Berlin-Heidelberg, pp. 27-40). Interestingly, the short-term application of D1/D5-receptor agonists (SKF38393 or 6-bromo-APB, 50 μM) can induce a slow-onset potentiation. This D1/D5-agonist-induced delayed-onset potentiation (D1/D5-LTP) resembles late-LTP, i.e. it is dependent on protein synthesis in the CA1 of rat hippocampal slices in vitro. The question arises as to whether D1/D5-LTP also requires glutamatergic stimulation, i.e. NMDA-receptor activation. We provide first evidence that a synergistic role of D1/D5- as well as NMDA-receptor-function is required in mediating processes relevant for the maintenance of this protein synthesis-dependent potentiation.

Original languageEnglish (US)
Pages (from-to)1547-1554
Number of pages8
JournalNeuropharmacology
Volume52
Issue number7
DOIs
StatePublished - Jun 1 2007

Fingerprint

Long-Term Potentiation
Maintenance
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Cell Polarity
Proteins
Berlin
RNA
In Vitro Techniques
aspartic acid receptor

Keywords

  • Cellular memory formation
  • Dopamine
  • Heterosynaptic late-LTP
  • Hippocampus
  • Late-LTP
  • Protein synthesis-dependent LTP

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Synergistic requirements for the induction of dopaminergic D1/D5-receptor-mediated LTP in hippocampal slices of rat CA1 in vitro. / Navakkode, Sheeja; Sajikumar, Sreedharan; Frey, Julietta Uta.

In: Neuropharmacology, Vol. 52, No. 7, 01.06.2007, p. 1547-1554.

Research output: Contribution to journalArticle

Navakkode, Sheeja ; Sajikumar, Sreedharan ; Frey, Julietta Uta. / Synergistic requirements for the induction of dopaminergic D1/D5-receptor-mediated LTP in hippocampal slices of rat CA1 in vitro. In: Neuropharmacology. 2007 ; Vol. 52, No. 7. pp. 1547-1554.
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