TY - JOUR
T1 - Synthesis, Absorption, and Fluorescence Studies of Coumaryl-Labelled Amino Acids and Dipeptides Linked Via Triazole Ring
AU - Panda, Siva S.
N1 - Funding Information:
The authors acknowledge the Department of Science and Technology (DST), New Delhi, for providing research grant (SB/FT/CS-033/2012) for the research work. DSA also thanks DST, New Delhi for the research fellowship. SK and SMAS thank UGC, New Delhi, India for their Junior Research Fellowship and BSR Fellowship, respectively.
Publisher Copyright:
© 2015 Journal compilation CSIRO.
PY - 2015
Y1 - 2015
N2 - Fluorophores based on 4-triazolyl, 7-hydroxy-4-triazolylmethyl, 4-O-triazolylmethyl, and 7-O-triazolylmethyl coumaryl-tagged amino acids and dipeptides were synthesized by copper-catalyzed [3+2] cycloaddition reaction between azido- or alkynyl-functionalized coumarins with alkynyl- or azido-functionalized amino acid and dipeptides in good-to-excellent yields. Steady-state absorption and the fluorescence properties of the synthesized conjugates were studied. The chemical applicability of these amino acid and peptide-based fluorophores was successfully demonstrated by their linear elongation by further tagging them with appropriate C- or N-terminus amino acid.
AB - Fluorophores based on 4-triazolyl, 7-hydroxy-4-triazolylmethyl, 4-O-triazolylmethyl, and 7-O-triazolylmethyl coumaryl-tagged amino acids and dipeptides were synthesized by copper-catalyzed [3+2] cycloaddition reaction between azido- or alkynyl-functionalized coumarins with alkynyl- or azido-functionalized amino acid and dipeptides in good-to-excellent yields. Steady-state absorption and the fluorescence properties of the synthesized conjugates were studied. The chemical applicability of these amino acid and peptide-based fluorophores was successfully demonstrated by their linear elongation by further tagging them with appropriate C- or N-terminus amino acid.
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U2 - 10.1071/CH14708
DO - 10.1071/CH14708
M3 - Article
AN - SCOPUS:84941044096
VL - 68
SP - 1415
EP - 1426
JO - Australian Journal of Chemistry
JF - Australian Journal of Chemistry
SN - 0004-9425
IS - 9
ER -