Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Amino acid conjugates of quinolone, metronidazole and sulfadiazine antibiotics were synthesized in good yields using benzotriazole methodology. All the conjugates were screened for their antibacterial activity using methods adapted from the Clinical and Laboratory Standards Institute. Antibiotic conjugates were tested for activity in four medically relevant organisms; Staphylococcus aureus (RN4220), Escherichia coli (DH5α), Pseudomonas aeruginosa (PAO1), and Bacillus subtilis (168). Several antibiotic conjugates show promising results against several of the strains screened.

Original languageEnglish (US)
Pages (from-to)1856-1861
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number7
DOIs
StatePublished - Apr 1 2014

Fingerprint

Anti-Bacterial Agents
Amino Acids
Sulfadiazine
Quinolones
Metronidazole
Bacilli
Bacillus subtilis
Pseudomonas aeruginosa
Escherichia coli
Staphylococcus aureus
benzotriazole

Keywords

  • Antibacterial
  • Antibiotics
  • Benzotriazole
  • Conjugates
  • Lipophilicity

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Medicine(all)

Cite this

Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates. / Panda, Siva S.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 24, No. 7, 01.04.2014, p. 1856-1861.

Research output: Contribution to journalArticle

@article{96f5c49e96654f8699e1dd16a6420f0d,
title = "Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates",
abstract = "Amino acid conjugates of quinolone, metronidazole and sulfadiazine antibiotics were synthesized in good yields using benzotriazole methodology. All the conjugates were screened for their antibacterial activity using methods adapted from the Clinical and Laboratory Standards Institute. Antibiotic conjugates were tested for activity in four medically relevant organisms; Staphylococcus aureus (RN4220), Escherichia coli (DH5α), Pseudomonas aeruginosa (PAO1), and Bacillus subtilis (168). Several antibiotic conjugates show promising results against several of the strains screened.",
keywords = "Antibacterial, Antibiotics, Benzotriazole, Conjugates, Lipophilicity",
author = "Panda, {Siva S.}",
year = "2014",
month = "4",
day = "1",
doi = "10.1016/j.bmcl.2014.01.065",
language = "English (US)",
volume = "24",
pages = "1856--1861",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "7",

}

TY - JOUR

T1 - Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates

AU - Panda, Siva S.

PY - 2014/4/1

Y1 - 2014/4/1

N2 - Amino acid conjugates of quinolone, metronidazole and sulfadiazine antibiotics were synthesized in good yields using benzotriazole methodology. All the conjugates were screened for their antibacterial activity using methods adapted from the Clinical and Laboratory Standards Institute. Antibiotic conjugates were tested for activity in four medically relevant organisms; Staphylococcus aureus (RN4220), Escherichia coli (DH5α), Pseudomonas aeruginosa (PAO1), and Bacillus subtilis (168). Several antibiotic conjugates show promising results against several of the strains screened.

AB - Amino acid conjugates of quinolone, metronidazole and sulfadiazine antibiotics were synthesized in good yields using benzotriazole methodology. All the conjugates were screened for their antibacterial activity using methods adapted from the Clinical and Laboratory Standards Institute. Antibiotic conjugates were tested for activity in four medically relevant organisms; Staphylococcus aureus (RN4220), Escherichia coli (DH5α), Pseudomonas aeruginosa (PAO1), and Bacillus subtilis (168). Several antibiotic conjugates show promising results against several of the strains screened.

KW - Antibacterial

KW - Antibiotics

KW - Benzotriazole

KW - Conjugates

KW - Lipophilicity

UR - http://www.scopus.com/inward/record.url?scp=84897424425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897424425&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2014.01.065

DO - 10.1016/j.bmcl.2014.01.065

M3 - Article

C2 - 24641976

AN - SCOPUS:84897424425

VL - 24

SP - 1856

EP - 1861

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 7

ER -