Synthesis and anticancer studies of novel n-benzyl pyridazinone derivatives

Mohamed Elagawany; Mohamed A. Ibrahim; Tarek S. Ibrahim; Amany M.M. Al-Mahmoudy; Alaa Moawad; Mohammed M. Ghoneim; Mohamed M. Radwan; Siva Shankar Panda

doi:10.2174/1570180814666170223111312

Synthesis and anticancer studies of novel n-benzyl pyridazinone derivatives

Mohamed Elagawany, Mohamed A. Ibrahim, Tarek S. Ibrahim, Amany M.M. Al-Mahmoudy, Alaa Moawad, Mohammed M. Ghoneim, Mohamed M. Radwan, Siva Shankar Panda

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Introduction: According to WHO, cancer is one of the most leading causes of death. Development of anticancer drugs draw considerable attention. Pyridazinones analogues were reported to possess anticancer properties. Chemical modification of pyridazinone may lead to potential anticancer agent. Objective: The objective of this article is to develop new pyridazinone deriatives and evaluate their anticancer activities. Results: The target compounds were synthesized using Palladium cross coupling reactions, Buchwald and Suzuki, the synthesized compound were evaluated against BT-549, KB and SK-MEL cell lines. Some compounds showed moderate to significant inhibitory activity. Conclusion: Novel pyridazinone derivatives were synthesized in a good yield. Some of the synthesized analogues showed good anticancer properties against BT-549, KB and SK-MEL cell lines.

Original language	English (US)
Pages (from-to)	1008-1013
Number of pages	6
Journal	Letters in Drug Design and Discovery
Volume	14
Issue number	9
DOIs	https://doi.org/10.2174/1570180814666170223111312
State	Published - Sep 1 2017

Keywords

Anti-inflammatory
Anticancer
Buwald coupling
Cardiovascular activities
Pyridazinone
Suzuki

ASJC Scopus subject areas

Molecular Medicine
Pharmaceutical Science
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/1570180814666170223111312

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title = "Synthesis and anticancer studies of novel n-benzyl pyridazinone derivatives",

abstract = "Introduction: According to WHO, cancer is one of the most leading causes of death. Development of anticancer drugs draw considerable attention. Pyridazinones analogues were reported to possess anticancer properties. Chemical modification of pyridazinone may lead to potential anticancer agent. Objective: The objective of this article is to develop new pyridazinone deriatives and evaluate their anticancer activities. Results: The target compounds were synthesized using Palladium cross coupling reactions, Buchwald and Suzuki, the synthesized compound were evaluated against BT-549, KB and SK-MEL cell lines. Some compounds showed moderate to significant inhibitory activity. Conclusion: Novel pyridazinone derivatives were synthesized in a good yield. Some of the synthesized analogues showed good anticancer properties against BT-549, KB and SK-MEL cell lines.",

keywords = "Anti-inflammatory, Anticancer, Buwald coupling, Cardiovascular activities, Pyridazinone, Suzuki",

author = "Mohamed Elagawany and Ibrahim, {Mohamed A.} and Ibrahim, {Tarek S.} and Al-Mahmoudy, {Amany M.M.} and Alaa Moawad and Ghoneim, {Mohammed M.} and Radwan, {Mohamed M.} and Panda, {Siva Shankar}",

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year = "2017",

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doi = "10.2174/1570180814666170223111312",

language = "English (US)",

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TY - JOUR

T1 - Synthesis and anticancer studies of novel n-benzyl pyridazinone derivatives

AU - Elagawany, Mohamed

AU - Ibrahim, Mohamed A.

AU - Ibrahim, Tarek S.

AU - Al-Mahmoudy, Amany M.M.

AU - Moawad, Alaa

AU - Ghoneim, Mohammed M.

AU - Radwan, Mohamed M.

AU - Panda, Siva Shankar

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Introduction: According to WHO, cancer is one of the most leading causes of death. Development of anticancer drugs draw considerable attention. Pyridazinones analogues were reported to possess anticancer properties. Chemical modification of pyridazinone may lead to potential anticancer agent. Objective: The objective of this article is to develop new pyridazinone deriatives and evaluate their anticancer activities. Results: The target compounds were synthesized using Palladium cross coupling reactions, Buchwald and Suzuki, the synthesized compound were evaluated against BT-549, KB and SK-MEL cell lines. Some compounds showed moderate to significant inhibitory activity. Conclusion: Novel pyridazinone derivatives were synthesized in a good yield. Some of the synthesized analogues showed good anticancer properties against BT-549, KB and SK-MEL cell lines.

AB - Introduction: According to WHO, cancer is one of the most leading causes of death. Development of anticancer drugs draw considerable attention. Pyridazinones analogues were reported to possess anticancer properties. Chemical modification of pyridazinone may lead to potential anticancer agent. Objective: The objective of this article is to develop new pyridazinone deriatives and evaluate their anticancer activities. Results: The target compounds were synthesized using Palladium cross coupling reactions, Buchwald and Suzuki, the synthesized compound were evaluated against BT-549, KB and SK-MEL cell lines. Some compounds showed moderate to significant inhibitory activity. Conclusion: Novel pyridazinone derivatives were synthesized in a good yield. Some of the synthesized analogues showed good anticancer properties against BT-549, KB and SK-MEL cell lines.

KW - Anti-inflammatory

KW - Anticancer

KW - Buwald coupling

KW - Cardiovascular activities

KW - Pyridazinone

KW - Suzuki

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U2 - 10.2174/1570180814666170223111312

DO - 10.2174/1570180814666170223111312

M3 - Article

AN - SCOPUS:85028926845

SN - 1570-1808

VL - 14

SP - 1008

EP - 1013

JO - Letters in Drug Design and Discovery

JF - Letters in Drug Design and Discovery

IS - 9

ER -

Synthesis and anticancer studies of novel n-benzyl pyridazinone derivatives

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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