Synthesis and anticancer studies of novel n-benzyl pyridazinone derivatives

Mohamed Elagawany, Mohamed A. Ibrahim, Tarek S. Ibrahim, Amany M.M. Al-Mahmoudy, Alaa Moawad, Mohammed M. Ghoneim, Mohamed M. Radwan, Siva Shankar Panda

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Introduction: According to WHO, cancer is one of the most leading causes of death. Development of anticancer drugs draw considerable attention. Pyridazinones analogues were reported to possess anticancer properties. Chemical modification of pyridazinone may lead to potential anticancer agent. Objective: The objective of this article is to develop new pyridazinone deriatives and evaluate their anticancer activities. Results: The target compounds were synthesized using Palladium cross coupling reactions, Buchwald and Suzuki, the synthesized compound were evaluated against BT-549, KB and SK-MEL cell lines. Some compounds showed moderate to significant inhibitory activity. Conclusion: Novel pyridazinone derivatives were synthesized in a good yield. Some of the synthesized analogues showed good anticancer properties against BT-549, KB and SK-MEL cell lines.

Original languageEnglish (US)
Pages (from-to)1008-1013
Number of pages6
JournalLetters in Drug Design and Discovery
Volume14
Issue number9
DOIs
StatePublished - Sep 1 2017

Keywords

  • Anti-inflammatory
  • Anticancer
  • Buwald coupling
  • Cardiovascular activities
  • Pyridazinone
  • Suzuki

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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    Elagawany, M., Ibrahim, M. A., Ibrahim, T. S., Al-Mahmoudy, A. M. M., Moawad, A., Ghoneim, M. M., Radwan, M. M., & Panda, S. S. (2017). Synthesis and anticancer studies of novel n-benzyl pyridazinone derivatives. Letters in Drug Design and Discovery, 14(9), 1008-1013. https://doi.org/10.2174/1570180814666170223111312