Synthesis and antimalarial bioassay of quinine - peptide conjugates

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25 Scopus citations

Abstract

Amino acid and peptide conjugates of quinine were synthesized using microwave irradiation in 52-95% yields using benzotriazole methodology. The majority of these conjugates retain in vitro antimalarial activity with IC50 values below 100 nm, similar to quinine.

Original languageEnglish (US)
Pages (from-to)361-6
Number of pages6
JournalChemical Biology and Drug Design
Volume82
Issue number4
DOIs
StatePublished - Oct 2013

Keywords

  • Antimalarials
  • Biological Assay
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Peptides
  • Quinine
  • Journal Article

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