Synthesis and antimicrobial activity of some new 4-triazolylmethoxy-2H- chromen-2-one derivatives

Siva S. Panda, Ritu Malik, Mahesh Chand, Subhash C. Jain

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

4-(5-Aryl-4H-[1,2,4]triazol-3-ylmethoxy)-2Hchromen-2-ones have been synthesized by the one pot cyclocondensation reaction of 2-(2-oxo-2H-chromen-4- yloxy)acetohydrazide with aromatic/heterocyclic aldehydes in the presence of ammonium acetate in acetic acid. The structures of all the new compounds have been established on the basis of their analytical and spectral data. These compounds were also evaluated for their antibacterial and antifungal activity against various strains of bacteria and fungi and some are found to possess significant antimicrobial activity when compared with ciprofloxacin and miconazole.

Original languageEnglish (US)
Pages (from-to)3750-3756
Number of pages7
JournalMedicinal Chemistry Research
Volume21
Issue number11
DOIs
StatePublished - Nov 1 2012
Externally publishedYes

Keywords

  • 4-Triazolylmethoxy-2H-chromen-2-ones
  • Antimicrobial activity
  • Cyclocondensation
  • Minimum bactericidal concentration
  • Minimum fungicidal concentration

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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