Synthesis and antimicrobial activity of some new 4-triazolylmethoxy-2H- chromen-2-one derivatives

Siva S. Panda; Ritu Malik; Mahesh Chand; Subhash C. Jain

doi:10.1007/s00044-011-9881-0

Synthesis and antimicrobial activity of some new 4-triazolylmethoxy-2H- chromen-2-one derivatives

Siva S. Panda, Ritu Malik, Mahesh Chand, Subhash C. Jain

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

4-(5-Aryl-4H-[1,2,4]triazol-3-ylmethoxy)-2Hchromen-2-ones have been synthesized by the one pot cyclocondensation reaction of 2-(2-oxo-2H-chromen-4- yloxy)acetohydrazide with aromatic/heterocyclic aldehydes in the presence of ammonium acetate in acetic acid. The structures of all the new compounds have been established on the basis of their analytical and spectral data. These compounds were also evaluated for their antibacterial and antifungal activity against various strains of bacteria and fungi and some are found to possess significant antimicrobial activity when compared with ciprofloxacin and miconazole.

Original language	English (US)
Pages (from-to)	3750-3756
Number of pages	7
Journal	Medicinal Chemistry Research
Volume	21
Issue number	11
DOIs	https://doi.org/10.1007/s00044-011-9881-0
State	Published - Nov 2012
Externally published	Yes

Keywords

4-Triazolylmethoxy-2H-chromen-2-ones
Antimicrobial activity
Cyclocondensation
Minimum bactericidal concentration
Minimum fungicidal concentration

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

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10.1007/s00044-011-9881-0

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title = "Synthesis and antimicrobial activity of some new 4-triazolylmethoxy-2H- chromen-2-one derivatives",

abstract = "4-(5-Aryl-4H-[1,2,4]triazol-3-ylmethoxy)-2Hchromen-2-ones have been synthesized by the one pot cyclocondensation reaction of 2-(2-oxo-2H-chromen-4- yloxy)acetohydrazide with aromatic/heterocyclic aldehydes in the presence of ammonium acetate in acetic acid. The structures of all the new compounds have been established on the basis of their analytical and spectral data. These compounds were also evaluated for their antibacterial and antifungal activity against various strains of bacteria and fungi and some are found to possess significant antimicrobial activity when compared with ciprofloxacin and miconazole.",

keywords = "4-Triazolylmethoxy-2H-chromen-2-ones, Antimicrobial activity, Cyclocondensation, Minimum bactericidal concentration, Minimum fungicidal concentration",

author = "Panda, {Siva S.} and Ritu Malik and Mahesh Chand and Jain, {Subhash C.}",

note = "Funding Information: Acknowledgments Siva S. Panda and Mahesh Chand are thankful to UGC (New Delhi) for financial assistance.",

year = "2012",

month = nov,

doi = "10.1007/s00044-011-9881-0",

language = "English (US)",

volume = "21",

pages = "3750--3756",

journal = "Medicinal Chemistry Research",

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publisher = "Birkhause Boston",

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TY - JOUR

T1 - Synthesis and antimicrobial activity of some new 4-triazolylmethoxy-2H- chromen-2-one derivatives

AU - Panda, Siva S.

AU - Malik, Ritu

AU - Chand, Mahesh

AU - Jain, Subhash C.

N1 - Funding Information: Acknowledgments Siva S. Panda and Mahesh Chand are thankful to UGC (New Delhi) for financial assistance.

PY - 2012/11

Y1 - 2012/11

N2 - 4-(5-Aryl-4H-[1,2,4]triazol-3-ylmethoxy)-2Hchromen-2-ones have been synthesized by the one pot cyclocondensation reaction of 2-(2-oxo-2H-chromen-4- yloxy)acetohydrazide with aromatic/heterocyclic aldehydes in the presence of ammonium acetate in acetic acid. The structures of all the new compounds have been established on the basis of their analytical and spectral data. These compounds were also evaluated for their antibacterial and antifungal activity against various strains of bacteria and fungi and some are found to possess significant antimicrobial activity when compared with ciprofloxacin and miconazole.

AB - 4-(5-Aryl-4H-[1,2,4]triazol-3-ylmethoxy)-2Hchromen-2-ones have been synthesized by the one pot cyclocondensation reaction of 2-(2-oxo-2H-chromen-4- yloxy)acetohydrazide with aromatic/heterocyclic aldehydes in the presence of ammonium acetate in acetic acid. The structures of all the new compounds have been established on the basis of their analytical and spectral data. These compounds were also evaluated for their antibacterial and antifungal activity against various strains of bacteria and fungi and some are found to possess significant antimicrobial activity when compared with ciprofloxacin and miconazole.

KW - 4-Triazolylmethoxy-2H-chromen-2-ones

KW - Antimicrobial activity

KW - Cyclocondensation

KW - Minimum bactericidal concentration

KW - Minimum fungicidal concentration

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U2 - 10.1007/s00044-011-9881-0

DO - 10.1007/s00044-011-9881-0

M3 - Article

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SN - 1054-2523

VL - 21

SP - 3750

EP - 3756

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 11

ER -

Synthesis and antimicrobial activity of some new 4-triazolylmethoxy-2H- chromen-2-one derivatives

Abstract

Keywords

ASJC Scopus subject areas

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