Synthesis and antimicrobial activity of some new 4-triazolylmethoxy-2H- chromen-2-one derivatives

Siva Shankar Panda, Ritu Malik, Mahesh Chand, Subhash C. Jain

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

4-(5-Aryl-4H-[1,2,4]triazol-3-ylmethoxy)-2Hchromen-2-ones have been synthesized by the one pot cyclocondensation reaction of 2-(2-oxo-2H-chromen-4- yloxy)acetohydrazide with aromatic/heterocyclic aldehydes in the presence of ammonium acetate in acetic acid. The structures of all the new compounds have been established on the basis of their analytical and spectral data. These compounds were also evaluated for their antibacterial and antifungal activity against various strains of bacteria and fungi and some are found to possess significant antimicrobial activity when compared with ciprofloxacin and miconazole.

Original languageEnglish (US)
Pages (from-to)3750-3756
Number of pages7
JournalMedicinal Chemistry Research
Volume21
Issue number11
DOIs
StatePublished - Nov 1 2012
Externally publishedYes

Fingerprint

Miconazole
Ciprofloxacin
Fungi
Aldehydes
Acetic Acid
Bacteria
Derivatives
ammonium acetate

Keywords

  • 4-Triazolylmethoxy-2H-chromen-2-ones
  • Antimicrobial activity
  • Cyclocondensation
  • Minimum bactericidal concentration
  • Minimum fungicidal concentration

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

Synthesis and antimicrobial activity of some new 4-triazolylmethoxy-2H- chromen-2-one derivatives. / Panda, Siva Shankar; Malik, Ritu; Chand, Mahesh; Jain, Subhash C.

In: Medicinal Chemistry Research, Vol. 21, No. 11, 01.11.2012, p. 3750-3756.

Research output: Contribution to journalArticle

Panda, Siva Shankar ; Malik, Ritu ; Chand, Mahesh ; Jain, Subhash C. / Synthesis and antimicrobial activity of some new 4-triazolylmethoxy-2H- chromen-2-one derivatives. In: Medicinal Chemistry Research. 2012 ; Vol. 21, No. 11. pp. 3750-3756.
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