Synthesis and biological evaluation of novel n-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl) methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl) formamide as a potent immunosuppressant agent

Chen Fan, Yubin Wang, Peng Lu, Xiaojian Xue, Jin-Xiong She

Research output: Contribution to journalArticle

Abstract

N-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl) methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl)-Formamide (1) was synthesized and its immunosuppressive activity was evaluated. The results showed it had highly immunosuppressive activity and can be studied as lead compound in the development of immunosuppressant agent.

Original languageEnglish (US)
Pages (from-to)375-379
Number of pages5
JournalLetters in Drug Design and Discovery
Volume11
Issue number3
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Thiadiazoles
Immunosuppressive Agents
formamide
benzofuran

Keywords

  • Formamide derivatives
  • Immunosuppressive bioactivity
  • Synthesis

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

Cite this

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title = "Synthesis and biological evaluation of novel n-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl) methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl) formamide as a potent immunosuppressant agent",
abstract = "N-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl) methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl)-Formamide (1) was synthesized and its immunosuppressive activity was evaluated. The results showed it had highly immunosuppressive activity and can be studied as lead compound in the development of immunosuppressant agent.",
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author = "Chen Fan and Yubin Wang and Peng Lu and Xiaojian Xue and Jin-Xiong She",
year = "2014",
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T1 - Synthesis and biological evaluation of novel n-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl) methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl) formamide as a potent immunosuppressant agent

AU - Fan, Chen

AU - Wang, Yubin

AU - Lu, Peng

AU - Xue, Xiaojian

AU - She, Jin-Xiong

PY - 2014/1/1

Y1 - 2014/1/1

N2 - N-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl) methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl)-Formamide (1) was synthesized and its immunosuppressive activity was evaluated. The results showed it had highly immunosuppressive activity and can be studied as lead compound in the development of immunosuppressant agent.

AB - N-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl) methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl)-Formamide (1) was synthesized and its immunosuppressive activity was evaluated. The results showed it had highly immunosuppressive activity and can be studied as lead compound in the development of immunosuppressant agent.

KW - Formamide derivatives

KW - Immunosuppressive bioactivity

KW - Synthesis

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