Synthesis and biological evaluation of novel n-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl) methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl) formamide as a potent immunosuppressant agent

Chen Fan; Yubin Wang; Peng Lu; Xiaojian Xue; Jinxiong She

doi:10.2174/15701808113106660084

Synthesis and biological evaluation of novel n-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl) methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl) formamide as a potent immunosuppressant agent

Chen Fan, Yubin Wang, Peng Lu, Xiaojian Xue, Jinxiong She

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

N-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl) methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl)-Formamide (1) was synthesized and its immunosuppressive activity was evaluated. The results showed it had highly immunosuppressive activity and can be studied as lead compound in the development of immunosuppressant agent.

Original language	English (US)
Pages (from-to)	375-379
Number of pages	5
Journal	Letters in Drug Design and Discovery
Volume	11
Issue number	3
DOIs	https://doi.org/10.2174/15701808113106660084
State	Published - Jan 2014
Externally published	Yes

Keywords

Formamide derivatives
Immunosuppressive bioactivity
Synthesis

ASJC Scopus subject areas

Molecular Medicine
Pharmaceutical Science
Drug Discovery

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10.2174/15701808113106660084

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Synthesis and biological evaluation of novel n-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl) methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl) formamide as a potent immunosuppressant agent. / Fan, Chen; Wang, Yubin; Lu, Peng et al.
In: Letters in Drug Design and Discovery, Vol. 11, No. 3, 01.2014, p. 375-379.

Research output: Contribution to journal › Article › peer-review

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title = "Synthesis and biological evaluation of novel n-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl) methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl) formamide as a potent immunosuppressant agent",

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AU - Wang, Yubin

AU - Lu, Peng

AU - Xue, Xiaojian

AU - She, Jinxiong

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Y1 - 2014/1

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AB - N-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl) methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl)-Formamide (1) was synthesized and its immunosuppressive activity was evaluated. The results showed it had highly immunosuppressive activity and can be studied as lead compound in the development of immunosuppressant agent.

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KW - Immunosuppressive bioactivity

KW - Synthesis

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Synthesis and biological evaluation of novel n-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl) methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl) formamide as a potent immunosuppressant agent

Abstract

Keywords

ASJC Scopus subject areas

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