Synthesis and biological evaluation of novel n-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl) methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl) formamide as a potent immunosuppressant agent

Chen Fan, Yubin Wang, Peng Lu, Xiaojian Xue, Jin-Xiong She

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

N-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl) methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl)-Formamide (1) was synthesized and its immunosuppressive activity was evaluated. The results showed it had highly immunosuppressive activity and can be studied as lead compound in the development of immunosuppressant agent.

Original languageEnglish (US)
Pages (from-to)375-379
Number of pages5
JournalLetters in Drug Design and Discovery
Volume11
Issue number3
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Formamide derivatives
  • Immunosuppressive bioactivity
  • Synthesis

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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