Synthesis and Characterization of Bionanomaterials and Evaluation of Their Antioxidant, Antibacterial, and DNA Cleavage Activities

Tuba Tarhan, Abdurrahman Dündar, Veysi Okumuş, Mustafa Çulha

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In this study, the hexagonal boron nitride (hBN) (1), poly-levodopa (P-L(DP) (2), P-L(DP) coated hBN (hBN@P(L-DP)) (3), and silver nanoparticles (AgNPs) decorated hBN@P(L-DP) (hBN@P(L-DP)-AgNPs) (4) were synthesized and characterized by multiple spectroscopic techniques. Additionally, their biological properties such as antioxidant, antibacterial, and DNA cleavage activities were determined. It is worth noting that, products 3 and 4 were newly synthesized structures. The antioxidant activities of all the nanomaterials 1, 2, 3, and 4 nanomaterials were investigated using some tests such as DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging and reducing power ability. Among the synthesized nanomaterials, product 2 exhibited the highest radical scavenging (64.8±1.94 %) and reducing power activity (0.61±0.017) at a concentration of 200 mg L−1. Product 4 was determined to have antibacterial activity against all three Gram-positive and three Gram-negative test bacteria. In addition, all the nanomaterials were tested for cleavage activity using pBR 322 plasmid DNA, as a result of which it was determined that only product 4 showed the ability of cleavage from both chains of DNA.

Original languageEnglish (US)
Pages (from-to)4217-4223
Number of pages7
JournalChemistrySelect
Volume6
Issue number17
DOIs
StatePublished - May 7 2021
Externally publishedYes

Keywords

  • Antioxidant activity
  • DNA cleavage activity
  • L-dopa
  • Nanomaterials
  • Silver Nanoparticles

ASJC Scopus subject areas

  • Chemistry(all)

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